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Anti-PDGF antibodies and methods for producing engineered antibodies

  • US 20030219839A1
  • Filed: 09/20/2002
  • Published: 11/27/2003
  • Est. Priority Date: 09/20/2001
  • Status: Abandoned Application
First Claim
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1. A method for providing an engineered antibody or antibody fragment comprising:

  • providing a panel of antibodies having specificity for a target, the panel of antibodies including a plurality of antibody members derived from a first species;

    determining the sequence of at least a portion of a first member of the panel of antibodies;

    comparing sequence of said first member of the panel to a reference library of antibody sequences or antibody fragment sequences from a target species, the target species being different from the first species;

    selecting at least one sequence from a first member of the reference library which demonstrates a high degree of homology to the sequence of said first member of the panel and which contains a FR3 region;

    obtaining the CDR3 region from said first member of the panel; and

    incorporating the CDR3 region from said first member of the panel adjacent to the FR3 region of the at least one sequence from the first member of the reference library to form an engineered antibody or antibody fragment.

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