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Secretion of proteins with multiple disulfide bonds in bacteria and uses thereof

  • US 20030219870A1
  • Filed: 03/24/2003
  • Published: 11/27/2003
  • Est. Priority Date: 03/23/2002
  • Status: Abandoned Application
First Claim
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1. A bacteria genetically transformed with an expression cassette comprising a leader peptide that directs protein export through the Twin Arginine Translocation pathway upstream of a gene encoding a heterologous polypeptide, and wherein the heterologous polypeptide is produced by the bacterial cell and comprises at least one disulfide bond.

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