Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses
First Claim
1. A device for separating epithelium from an eye having a cornea with epithelium and a stroma, the device comprising an epithelial delaminator member configured to apply a mechanical force beneath that epithelium to separate the epithelium from the stroma without cutting that stroma.
1 Assignment
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Accused Products
Abstract
These methods, devices, and structures are useful in the field of ophthalmology; the devices and methods relate variously to separating or lifting corneal epithelium from the eye preferably in a substantially continuous layer, placing a lens or other suitable ocular or medical device beneath the epithelial membrane, and to the resulting structures formed by those procedures. The de-epilthelialization devices generally utilize a non-cutting separator or dissector that is configured to separate the epithelium at a naturally occurring cleavage surface in the eye between the epithelium and the corneal stroma (Bowman'"'"'s membrane), specifically separating in the region of the lamina lucida. The separator or dissector may have a structure that rolls or vibrates (or both) at that cleavage surface or interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or a pocket. The epithelium may then be replaced on the cornea after a refractive procedure or after placement of an ocular lens (or other subepithelial device) on the eye. The subepithelial device may comprise a wide variety of synthetic, natural, or composite polymeric materials. The step of replacing epithelial tissue upon the subepithelial device or upon the anterior corneal surface promotes epithelial healing.
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Citations
124 Claims
- 1. A device for separating epithelium from an eye having a cornea with epithelium and a stroma, the device comprising an epithelial delaminator member configured to apply a mechanical force beneath that epithelium to separate the epithelium from the stroma without cutting that stroma.
- 42. A device for lifting epithelium from an eye having a cornea with an anterior surface comprising an epithelial delaminator configured to apply a mechanical force to the anterior surface to lift the epithelium in a continuous layer.
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69. A method for lifting epithelium from an eye having a cornea with an epithelium and stroma, comprising the steps of:
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placing an epithelial delaminator member between the epithelium and the corneal stroma, and moving the epithelial delaminator member to apply a mechanical force beneath the epithelium with a force sufficient to lift the epithelium in a continuous layer but not to cut the stroma. - View Dependent Claims (70, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85)
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86. A method for changing the vision of an eye having an anterior corneal surface and an epithelial tissue layer, the method comprising the step of:
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lifting from the anterior corneal surface, a substantially continuous epithelial layer with a flap portion connected to the corneal surface to produce an epithelial tissue flap, introducing an implant onto the corneal anterior surface, and placing the attached epithelial tissue flap onto the implant. - View Dependent Claims (87, 88, 89, 90, 91)
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- 92. A device for lifting epithelium from an eye having a cornea with an anterior surface comprising an epithelial delaminator configured to apply a chemical composition to the anterior surface to lift the epithelium in a continuous layer.
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108. A method for lifting epithelium from an eye having a cornea with an anterior surface comprising the steps of:
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contacting the anterior surface with an epithelial delaminator and applying a mechanical force to the anterior surface, wherein the force is in an amount sufficient to lift the epithelium in a continuous layer to form an epithelial flap. - View Dependent Claims (109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124)
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Specification