Attachment of absorbable tissue scaffolds ot fixation devices

• US 20030220700A1
• Filed: 05/22/2002
• Published: 11/27/2003
• Est. Priority Date: 05/22/2002
• Status: Active Grant

• Current Assignee: Endo-Surgery, Inc.
• Original Assignee: Advanced Technologies and Regenerative Medicine, LLC
• Inventors: Contiliano, Joseph H., Hammer, Joseph J., Vyakarnam, Murty N., Brown, Kelly R.
• Granted Patent: US 8,187,326 B2
• Time in Patent Office: Days
• US Class Current: 623/23.58
• CPC Class Codes: A61B 17/0642 for bones, e.g. for osteosynthesis or connecting tendon to bone
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/0646 for insertion into cartillege, e.g. meniscus
• CPC Class Codes: A61B 2017/0647 having one single leg, e.g. tacks
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30749 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30065 thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
• CPC Class Codes: A61F 2002/30233 Stepped cylinders, i.e. having discrete diameter changes
• CPC Class Codes: A61F 2002/30324 differing in thickness
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30751 for attaching cartilage scaffolds to underlying bone
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2002/30878 with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
• CPC Class Codes: A61F 2002/30879 Ribs
• CPC Class Codes: A61F 2002/30891 Plurality of protrusions
• CPC Class Codes: A61F 2002/30957 : using a positive or a negative model, e.g. moulds
• CPC Class Codes: A61F 2002/30971 : Laminates, i.e. layered products
• CPC Class Codes: A61F 2210/0004 : bioabsorbable
• CPC Class Codes: A61F 2210/0071 : thermoplastic
• CPC Class Codes: A61F 2220/005 : using adhesives
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0036 : differing in thickness
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00029 : Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
• CPC Class Codes: A61F 2310/00179 : Ceramics or ceramic-like structures
• CPC Class Codes: A61F 2310/00203 : containing alumina or aluminium oxide
• CPC Class Codes: A61F 2310/00239 : containing zirconia or zirconium oxide ZrO2
• CPC Class Codes: A61F 2310/00293 : containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00329 : Glasses, e.g. bioglass
• CPC Class Codes: A61F 2310/00341 : Coral, e.g. aragonite, porite
• CPC Class Codes: A61F 2310/00353 : Bone cement, e.g. polymethylmethacrylate or PMMA
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 27/18 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/58 : Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.

Claims

1. A tissue scaffold implant device, comprising:

a tissue scaffold component,

a scaffold fixation component, and

an adhesive layer between said scaffold component and said fixation component, said adhesive layer comprising a polymer,

wherein said scaffold component is fixedly attached to said fixation component by said adhesive layer.

2. The device of claim 1 wherein said polymer is soluble.

3. The device of claim 2 wherein said tissue scaffold component comprises a soluble polymer.

4. The device of claim 3 wherein said fixation component comprises a soluble polymer.

5. The device of claim 4 wherein said soluble polymers comprise a bioabsorbable polymer.

6. The device of claim 5 wherein said bioabsorbable polymer is selected from the group consisting of aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes.

7. The device of claim 6 wherein said aliphatic polyesters are selected from the group consisting of homopolymer and copolymers of lactic acid, lactide (including L-, D-, meso and D,L mixtures), glycolic acid, glycolide, ε

-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), δ

-valerolactone, β

-butyrolactone, ε

-decalactone, 2,5-diketomorpholine, pivalolactone, α

,α

-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, γ

-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one and 6,8-dioxabicycloctane-7-one.

8. The device of claim 3 wherein said soluble polymer comprises a bioabsorbable polymer.

9. The device of claim 1 wherein said polymer is thermoplastic.

10. The device of claim 9 wherein said tissue scaffold component comprises a thermoplastic polymer.

11. The device of claim 10 wherein said fixation component comprises a thermoplastic polymer.

12. The device of claim 11 wherein said thermoplastic polymer comprises a bioabsorbable polymer.

13. A method of making a tissue scaffold implant device, comprising:

placing a polymer solution comprising a soluble polymer dissolved in a suitable solvent therefore onto a proximate surface of at least one of a tissue scaffold component and a tissue scaffold support component,

placing the proximate surfaces of said tissue scaffold and tissue scaffold support components in contact one with the other, and

removing the solvent from said polymer solution, thereby providing fixed attachment of said tissue scaffold support component to said tissue scaffold component.

14. The method of claim 13 wherein said soluble polymer comprises a bioabsorbable polymer.

15. The method of claim 14 wherein said bioabsorbable polymer is selected from the group consisting of aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes.

16. The method of claim 15 wherein said aliphatic polyesters are selected from the group consisting of homopolymer and copolymers of lactic acid, lactide (including L-, D-, meso and D,L mixtures), glycolic acid, glycolide, ε

-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), δ

-valerolactone, β

-butyrolactone, ε

-decalactone, 2,5-diketomorpholine, pivalolactone, α

,α

-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, γ

-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one and 6,8-dioxabicycloctane-7-one.

17. The method of claim 13 wherein said polymer solution is applied to said proximate surface of said tissue scaffold component.

18. A method of making a tissue scaffold implant device, comprising:

placing a thermoplastic polymer sheet on a proximate surface of a fixation component,

placing a proximate surface of a tissue scaffold component on said thermoplastic polymer sheet,

applying sufficient heat to melt said thermoplastic polymer sheet, and

cooling said thermoplastic polymer sheet, thereby providing fixed attachment of said fixation component to said tissue scaffold component.