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Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone

  • US 20030224051A1
  • Filed: 05/28/2003
  • Published: 12/04/2003
  • Est. Priority Date: 05/31/2002
  • Status: Abandoned Application
First Claim
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1. A controlled release oral dosage form for once-a-day administration of oxycodone comprising:

  • (a) a drug core which comprises;

    (i) an osmotic agent; and

    (ii) a low dose of oxycodone, or one or more pharmaceutically-acceptable salts thereof;

    (b) a semipermeable membrane at least partially surrounding the drug core; and

    (c) an exit orifice through the semipermeable membrane which communicates with the drug core so as to allow release of the oxycodone to the environment;

    wherein the drug core upon hydration in the environment exhibits a viscosity of about 50 cps to 100 cps.

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