Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
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Abstract
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula
wherein A, B, X, Y, R1, R2 and R3 are as described herein.
A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.
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Citations
21 Claims
- 1. A compound of the following formula I
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19. A method for treating diabetes, insulin resistance, obesity, hyperglycemia, hyperinsulinemia, elevated fatty acids or glycerol, Syndrome X, atherosclerosis or inflammation which comprises administering an effective amount of at least one compound of formula I
- 20. A method for treating diabetes, insulin resistance, obesity, hyperglycemia, hyperinsulinemia, elevated fatty acids or glycerol, Syndrome X, atherosclerosis or inflammation which comprises administering an effective amount of at least one dual aP2/k-FABP inhibitor.
Specification