Directed tissue growth employing reduced pressure
First Claim
1. An appliance for administering a reduced pressure treatment to promote directed growth of a tissue comprising:
- (a) a cover adapted to cover and enclose a tissue to be grown and adapted to maintain reduced pressure at the site of the tissue;
(b) a seal adapted to seal the cover about the tissue;
(c) reduced pressure supply means for connection to a source of suction, the reduced pressure supply means cooperating with the cover to supply the reduced pressure beneath the cover; and
(d) a bone substitute material adapted to promote tissue growth therein, the bone substitute material being located between the tissue and the cover.
2 Assignments
0 Petitions
Accused Products
Abstract
A tissue growth apparatus and method are provided for growing tissue by applying a tissue growth medium to the tissue and applying reduced, sub-atmospheric pressure at the growth medium and the tissue in a controlled manner for a selected time period. The application of reduced pressure at the growth medium and tissue promotes growth of the tissue within the tissue growth medium. The apparatus includes a tissue cover sealed over a tissue site. The apparatus also includes a tissue growth medium located beneath the tissue cover and in contact with the tissue to be grown. A vacuum pump supplies suction within the tissue cover over the tissue site to provide reduced pressure to the tissue and the tissue growth medium.
311 Citations
114 Claims
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1. An appliance for administering a reduced pressure treatment to promote directed growth of a tissue comprising:
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(a) a cover adapted to cover and enclose a tissue to be grown and adapted to maintain reduced pressure at the site of the tissue;
(b) a seal adapted to seal the cover about the tissue;
(c) reduced pressure supply means for connection to a source of suction, the reduced pressure supply means cooperating with the cover to supply the reduced pressure beneath the cover; and
(d) a bone substitute material adapted to promote tissue growth therein, the bone substitute material being located between the tissue and the cover. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An apparatus for growing a tissue, comprising:
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vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bone substitute material for positioning at the tissue within the sealing means and adapted to promote tissue growth therein. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for applying sub-atmospheric pressure to a tissue to be grown beneath a fluid-impermeable seal comprising:
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a bone substitute material for positioning beneath the seal configured to overlie the tissue such that the sub-atmospheric pressure is maintained within the bone substitute material and is applied to the tissue; and
a flexible tube having an inlet end inserted into the bone substitute material and an outlet end for extending from beneath the seal for supplying the sub-atmospheric pressure. - View Dependent Claims (23, 24)
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25. An apparatus for growing a tissue, comprising:
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a bone substitute material configured to overlie a tissue to be grown;
a fluid-impermeable cover overlying the bone substitute material, the cover adapted to form a seal with the region surrounding the tissue for maintaining sub-atmospheric pressure beneath the cover; and
a tubular member having a first end inserted within a portion of the bone substitute material and having a second end extending from beneath the cover to a location external to the cover for supplying sub-atmospheric pressure beneath the cover. - View Dependent Claims (26, 27, 28)
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29. An apparatus for growing a tissue, comprising:
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vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bone substitute material for positioning at the tissue within the sealing means, the bone substitute material having a pore size sufficiently large to permit tissue growth therein. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. An apparatus for growing a tissue comprising:
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a bone substitute material configured to overlie the tissue;
a cover overlying the bone substitute material, the cover adapted to form a seal with the region surrounding the tissue for maintaining a sub-atmospheric pressure beneath the cover;
a tubular member having a first end inserted within a portion of the bone substitute material and having a second end extending from beneath the cover to a location external to the cover; and
a vacuum source connected with the second end of the tubular member for supplying the sub-atmospheric pressure to the tissue. - View Dependent Claims (40, 41, 42, 43, 44, 45)
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46. An apparatus for growing a tissue comprising:
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a bioabsorbable scaffold material configured to overlie the tissue, the scaffold material having a pore size sufficiently large to permit tissue growth therein;
an open-cell foam section in communication with the scaffold material;
a cover overlying the scaffold material and the foam section, the cover adapted to form a seal with the region surrounding the tissue for maintaining a sub-atmospheric pressure beneath the cover; and
a tubular member having a first end inserted within a portion of the foam section and having a second end extending from beneath the cover to a location external to the cover for supplying the sub-atmospheric pressure beneath the cover. - View Dependent Claims (47, 48)
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49. An appliance for administering a reduced pressure treatment to promote directed growth of a tissue comprising:
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(a) a cover adapted to cover and enclose a tissue to be grown and adapted to maintain reduced pressure at the site of the tissue;
(b) a seal adapted to seal the cover about the tissue;
(c) reduced pressure supply means for connection to a source of suction, the reduced pressure supply means cooperating with the cover to supply the reduced pressure beneath the cover; and
(d) a bioabsorbable scaffold material for promoting tissue growth therein configured to be located between the tissue and the cover. - View Dependent Claims (50, 51, 52, 53, 54, 55)
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56. An apparatus for growing a tissue, comprising:
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vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bioabsorbable scaffold material for positioning at the tissue within the sealing means and adapted to promote tissue growth therein. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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72. An apparatus for applying sub-atmospheric pressure to a tissue to be grown beneath a fluid-impermeable seal comprising:
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a bioabsorbable scaffold material for positioning beneath the seal configured to overlie the tissue; and
a flexible tube having an inlet end inserted into the scaffold material and an outlet end for extending from beneath the seal for supplying a sub-atmospheric pressure to the tissue. - View Dependent Claims (73, 74, 75)
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76. An apparatus for growing a tissue, comprising:
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a bioabsorbable scaffold material configured to overlie a tissue to be grown;
an open-cell foam section in communication with the scaffold material;
a fluid-impermeable cover overlying the scaffold material and the foam section, the cover adapted to form a seal with the region surrounding the tissue for maintaining sub-atmospheric pressure beneath the cover; and
a tubular member having a first end inserted within a portion of the foam section and having a second end extending from beneath the cover to a location external to the cover for supplying sub-atmospheric pressure beneath the cover. - View Dependent Claims (77, 78)
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79. An apparatus for growing a tissue, comprising:
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vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bioabsorbable scaffold material for positioning at the tissue within the sealing means, the scaffold material having a pore size sufficiently large to permit tissue growth therein. - View Dependent Claims (80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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90. An apparatus for growing a tissue comprising:
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a bioabsorbable scaffold material configured to overlie the tissue;
a cover overlying the scaffold material, the cover adapted to form a seal with the region surrounding the tissue for maintaining a sub-atmospheric pressure beneath the cover;
a tubular member having a first end inserted within a portion of the scaffold material and having a second end extending from beneath the cover to a location external to the cover; and
a vacuum source connected with the second end of the tubular member for supplying the sub-atmospheric pressure to the tissue. - View Dependent Claims (91, 92, 93, 94, 95)
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96. A method of growing a tissue comprising the steps of:
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(a) providing a tissue growth medium proximate the tissue;
(b) applying a sub-atmospheric pressure to a tissue to be grown; and
(c) maintaining the sub-atmospheric pressure until the tissue has progressed toward a selected stage of growth within the tissue growth medium. - View Dependent Claims (97, 98, 99, 100, 101, 102, 103, 104)
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105. A method for growing a tissue comprising the steps of:
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(a) applying a sub-atmospheric pressure to a tissue to be grown, wherein the applying step comprises the steps of;
(i) placing a tissue growth medium in contact with a tissue to be grown;
(ii) locating a cover over the tissue;
(iii) sealing the periphery of the cover about the tissue; and
(iv) operably connecting the cover with a vacuum system for producing the sub-atmospheric pressure; and
(b) maintaining the sub-atmospheric pressure until the tissue has progressed toward a selected stage of growth within the tissue growth medium. - View Dependent Claims (106, 107, 108, 109, 110, 111, 112, 113)
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114. A method for growing new bone tissue from existing bone tissue comprising the steps of:
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(a) placing a bone substitute material in contact with the existing bone tissue to provide a matrix in which to grow new bone tissue;
(b) locating a cover over the existing bone tissue and the bone substitute material to form a sealed chamber at the bone tissue and the bone substitute material;
(c) providing a subatmospheric pressure within the chamber; and
(d) maintaining the sub-atmospheric pressure within the chamber until new bone tissue of a desired amount is grown within the bone substitute material.
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Specification