Composite material for wound repair

• US 20030225355A1
• Filed: 04/01/2003
• Published: 12/04/2003
• Est. Priority Date: 10/01/1998
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Butler, Charles E.
• Application Number:
  US10/406,153
• Publication Number:
  US 20030225355A1
• Time in Patent Office: Days
• US Class Current: 602/48
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/362 Skin, e.g. dermal papillae
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3813 Epithelial cells, e.g. keratinocytes, urothelial cells
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 31/129 containing macromolecular fillers

Abstract

A composite comprising a barrier material and a support material used for wound or tissue repair. Benefits include decreased adhesion to organs or other structures adjacent to the repair site, limited fluid flux, increased vascularization and cellular infiltration, decreased inflammation and reduced scar tissue formation.

Claims

1. A composition for wound repair comprising a biodegradable barrier material integrated with a support material.

2. The composition of claim 1, wherein the barrier material is comprised of dermal or epithelial tissue.

3. The composition of claim 2, wherein the dermal tissue is selected from the group consisting of epithelium, glands, vascular cells, vascular networks, fibroblasts, and, keratinocytes.

4. The composition of claim 1, wherein the barrier material is comprised of mucosal tissue.

5. The composition of claim 4, wherein the mucosal tissue is selected from the group consisting of esophagus, stomach, large intestine, small intestine, bladder, uterus, pericardium, glands, fibroblasts, smooth muscle cells, gastric cells, uro-epithelial cells, respiratory epithelial cells, oral endothelial cells and vascular endothelial cells.

6. The composition of claim 1, wherein the barrier material is comprised of tissues or cells selected from the group consisting of pleura, fascia, tendon, dura, pericardium, mesothelium, blood vessels, synovial surfaces, joint tissues, fat, and amnionic membrane.

7. The composition of claim 1, wherein the barrier material comprises acellular structures.

8. The composition of claim 7, wherein the acellular structure is selected from the group consisting of extracellular matrix, ground substance, polysaccharide matrix, protein matrix, basement membrane, fibrin, laminin, hyaluronic acid, bamacan, heparin sulfate proteoglycan, perlecan, agrin, collagen, intactin, decellularized tissue including the basement membrane, decellularized tissue excluding the basement membrane, particulate decellularized tissue, a soft-tissue graft, bioresorbable hyaluronic-based material, carboxymethylcellulose, oxidized regenerated cellulose, and gelatin foam.

9. The composition of claim 1, wherein the barrier material comprises a collagen-glucosaminoglycan matrix.

10. The composition of claim 1, wherein the support material is selected from the group consisting of host tissue, allogenic tissue, homogenic tissue, autologous tissue, and xenogenic tissue.

11. The composition of claim 1, wherein the support material is a synthetic material selected from the group consisting of polypropylene, polyester, silicone, polyethylene, polyamide, titanium, stainless steel, polymethylmethacrylate, silk, cotton, polyglactic acid, polyglycolic acid, poliglecaprone, collagen, polydioxone, and polytetrafluoroethylene.

12. The composition of claim 1, further comprising an anti-adhesive.

13. The composition of claim 12, wherein the anti-adhesive is selected from the group consisting of heparin, streptokinase, urokinase, ancrod, and tissue plasminogen activator.

14. The composition of claim 1 further comprising an anti-inflammatory.

15. The composition of claim 14, wherein the anti-inflammatory is selected from the group consisting of steroids, non-steroidal anti-inflammatory agents, and chemotherapeutic agents.

16. The composition of claim 1 further comprising a growth factor.

17. The composition of claim 16, wherein the growth factor is selected from the group consisting of vascular endothelial growth factors, platelet-derived growth factors, epidermal growth factors, insulin-like growth factors, transforming growth factor beta, and fibroblast growth factor.

18. The composition of claim 1 further comprising a substance selected from the group consisting of antibiotics, antiviral agents, growth-inhibiting agents, antithrombotic agents, prothrombotic agents, immunosuppressive agents, angiogenic agents and anti-angiogenic agents.

19. The composition of claim 1, wherein the barrier material is attached to the support material using an adhesive.

20. The composition of claim 19, wherein the adhesive is selected from the group consisting of cyanoacrylate, glue, fibrin glue, fibrin, thrombin, plasma, platelet-poor plasma, platelet-rich plasma, polyactide, and cellular-derived hemostatic agents.

21. The composition of claim 1, wherein the barrier material is attached to the support material using a mechanical agent selected from the group consisting of sutures, staples, and lamination.

22. The composition of claim 1, wherein the support material is substantially encased by the barrier material.

23. A method of repairing a wound comprising:

(a) preparing the wound area;

(b) draping the wound with the composite of claim 1;

(c) attaching the composite to the wound area; and

(d) covering or closing the wound.

24. The method of claim 23 wherein the wound for repair is selected from the group consisting of pelvic defects, joint defects, abdominal defects, chest wall defects, cranial defects, hernias, congenital abnormalities, skin lesions, burns, surgical incisions, and traumatic wounds.

25. A composition for wound repair comprising a barrier material and a support material, wherein the barrier material is acellular dermal tissue.

26. The composition of claim 25, wherein the support material is polypropylene.

27. The composition of claim 25, further comprising an anti-adhesive.

28. The composition of claim 27, wherein the anti-adhesive is selected from the group consisting of heparin, streptokinase, urokinase, ancrod, and tissue plasminogen activator.

29. The composition of claim 25 further comprising an anti-inflammatory.

30. The composition of claim 29, wherein the anti-inflammatory is selected from the group consisting of steroids, non-steroidal anti-inflammatory agents, and chemotherapeutic agents.

31. The composition of claim 25 further comprising a growth factor.

32. The composition of claim 31, wherein the growth factor is selected from the group consisting of vascular endothelial growth factors, platelet-derived growth factors, epidermal growth factors, insulin-like growth factors, transforming growth factor beta, and fibroblast growth factor.

33. The composition of claim 25 further comprising a substance selected from the group consisting of antibiotics, antiviral agents, growth-inhibiting agents antithrombotic agents, prothrombotic agents, immunosuppressive agents, angiogenic agents and anti-angiogenic agents.

34. The composition of claim 25, wherein the barrier material is attached to the support material using an adhesive.

35. The composition of claim 34, wherein the adhesive is selected from the group consisting of cyanoacrylate, glue, fibrin glue, fibrin, thrombin, plasma, platelet-poor plasma, platelet-rich plasma, polyactide, and cellular-derived hemostatic agents.

36. The composition of claim 25, wherein the barrier material is attached to the support material using a mechanical agent selected from the group consisting of sutures, staples, and lamination.

37. The composition of claim 25, wherein the support material is substantially encased by the barrier material.

38. A method of repairing a wound comprising:

(a) preparing the wound area;

(b) draping the wound with the composite of claim 25;

(c) attaching the composite to the wound area; and

(d) covering or closing the wound.

39. The method of claim 38 wherein the wound for repair is selected from the group consisting of pelvic defects, joint defects, abdominal defects, chest wall defects, cranial defects, hernias, congenital abnormalities, skin lesions, burns, surgical incisions, and traumatic wounds.