Attachment of absorbable tissue scaffolds to fixation devices

• US 20030225459A1
• Filed: 05/31/2002
• Published: 12/04/2003
• Est. Priority Date: 05/31/2002
• Status: Active Grant

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Contiliano, Joseph H., Hammer, Joseph J., Schwartz, Herbert Eugene
• Granted Patent: US 6,989,034 B2
• Time in Patent Office: Days
• US Class Current: 623/23.72
• CPC Class Codes: A61F 2/30742 Bellows or hose-like seals; Sealing membranes A61B17/8808 takes precedence; sealing membranes for retaining bone substitute A61F2/2846
• CPC Class Codes: A61F 2/30749 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30004 the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30225 Flat cylinders, i.e. discs
• CPC Class Codes: A61F 2002/30233 Stepped cylinders, i.e. having discrete diameter changes
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30461 sutured, ligatured or stitched
• CPC Class Codes: A61F 2002/30462 retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2002/30477 using sharp protrusions, e.g. spikes, for anchoring into connecting prosthetic part
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30751 for attaching cartilage scaffolds to underlying bone
• CPC Class Codes: A61F 2002/30757 made of a sheet covering the natural articular surface, e.g. cap
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2002/30785 parallel
• CPC Class Codes: A61F 2002/30878 with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
• CPC Class Codes: A61F 2002/30879 : Ribs
• CPC Class Codes: A61F 2002/30891 : Plurality of protrusions
• CPC Class Codes: A61F 2002/30957 : using a positive or a negative model, e.g. moulds
• CPC Class Codes: A61F 2002/30973 : Two joined adjacent layers having complementary interlocking protrusions and recesses
• CPC Class Codes: A61F 2210/0004 : bioabsorbable
• CPC Class Codes: A61F 2220/0025 : Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/0075 : sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0014 : having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00029 : Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
• CPC Class Codes: A61F 2310/00203 : containing alumina or aluminium oxide
• CPC Class Codes: A61F 2310/00239 : containing zirconia or zirconium oxide ZrO2
• CPC Class Codes: A61F 2310/00293 : containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00329 : Glasses, e.g. bioglass
• CPC Class Codes: A61F 2310/00341 : Coral, e.g. aragonite, porite
• CPC Class Codes: A61F 2310/00353 : Bone cement, e.g. polymethylmethacrylate or PMMA
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 27/18 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/58 : Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via at least one of sutures, fabrics, fibers, threads, elastomeric bands, reinforcing elements and interlocking protrusions for engaging and maintaining the scaffold component fixedly attached to the fixation component.

Claims

1. A tissue scaffold implant device, comprising:

a tissue scaffold component; and

a fixation component comprising a tissue scaffold support component,

wherein said tissue scaffold component is fixedly attached to said fixation component via an attachment means selected from the group consisting of fibers, sutures, ties, threads, elastomeric bands, fabrics, reinforcing elements partially embedded in said tissue scaffold component and interlocking protrusions on said tissue scaffold support for engaging and maintaining said tissue scaffold component fixedly attached to said fixation component.

2. The device of claim 1 wherein said tissue scaffold component comprises a bioabsorbable polymer.

3. The device of claim 1 wherein said fixation component comprises a bioabsorbable polymer.

4. The device of claim 1 wherein said attachment means comprises sutures.

5. The device of claim 4 wherein said sutures comprise a bioabsorbable polymer.

6. The device of claim 5 wherein said tissue scaffold component and said fixation component comprise a bioabsorbable polymer.

7. The device of claim 6 wherein said bioabsorbable polymer is selected from the group consisting of aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes.

8. The device of claim 7 wherein said aliphatic polyesters are selected from the group consisting of homopolymer and copolymers of lactic acid, lactide (including L-, D-, meso and D,L mixtures), glycolic acid, glycolide, ε

-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), -valerolactone, -butyrolactone, -decalactone, 2,5-diketomorpholine, pivalolactone, -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, -butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one and 6,8-dioxabicycloctane-7-one.

9. The device of claim 1,

wherein said tissue scaffold component is encased in said fabric and said fabric is fixedly attached to said fixation component via said suture, tie, thread, elastomeric band or fiber.

10. The device of claim 9 wherein said fabric is fixedly attached to said fixation component via said suture.

11. The device of claim 10 wherein said suture, said tissue scaffold component, said fixation component and said fabric comprise a bioabsorbable polymer.

12. The device of claim 11 wherein said bioabsorbable polymer is selected from the group consisting of aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes.

13. The device of claim 1 wherein said tissue scaffold component comprises a porous, lyophilized polymeric foam having partially embedded therein said reinforcing element and wherein said reinforcing element is fixedly attached to said fixation component by said suture, fiber, tie, thread or elastomeric band.

14. The device of claim 13 wherein said reinforcing element is fixedly attached to said fixation component by said suture.

15. The device of claim 14 wherein said suture, said tissue scaffold component, said fixation component and said reinforcing element comprise a bioabsorbable polymer.

16. The device of claim 15 wherein said bioabsorbable polymer is selected from the group consisting of aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes.

17. The device of claim 1 wherein said tissue scaffold support component comprises at least one of said interlocking protrusions for engaging and maintaining said tissue scaffold component fixedly attached to said tissue scaffold support component and wherein said tissue scaffold component comprises a material which can be penetrated by said protrusion and in which said protrusion may be embedded.

18. The device of claim 17 wherein said tissue scaffold component and said fixation component comprise a bioabsorbable polymer.

19. The device of claim 18 wherein said bioabsorbable polymer is selected from the group consisting of aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes.

20. The device of claim 19 wherein said aliphatic polyesters are selected from the group consisting of homopolymer and copolymers of lactic acid, lactide (including L-, D-, meso and D,L mixtures), glycolic acid, glycolide, ε

-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), -valerolactone, -butyrolactone, -decalactone, 2,5-diketomorpholine, pivalolactone, -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, -butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one and 6,8-dioxabicycloctane-7-one.