Novel chromium (III) alpha amino acid complexes

• US 20030228394A1
• Filed: 05/31/2002
• Published: 12/11/2003
• Est. Priority Date: 05/31/2002
• Status: Active Grant

• Current Assignee: Zinpro Corporation
• Original Assignee: Zinpro Corporation
• Inventors: Abdel-Monem, Mahamoud M., Anderson, Michael D.
• Granted Patent: US 7,247,328 B2
• Time in Patent Office: Days
• US Class Current: 426/74
• CPC Class Codes: A23K 20/30 Oligoelements
• CPC Class Codes: A23L 33/165 Complexes or chelates
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/0628 Leucine
• CPC Class Codes: A23V 2250/0632 Methionine
• CPC Class Codes: A23V 2250/1586 Chromium
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: C07F 11/005 compounds without a metal-carbon linkage

Abstract

Chromium (III) 1:3 complexes of alpha amino acids and their use as animal nutritional supplements.

Claims

1. A chromium complex of the formula:

2. The complex of claim 1 wherein “

X”

is monovalent.

3. The complex of claim 1 wherein “

X”

is selected from the group consisting of chloride, bromide, iodide, sulphate, phosphate, acetate and propionate.

4. The complex of claim 1 wherein “

R”

is selected so that the natural amino acid is one selected from the group consisting of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine and glycine.

11. The method of claim 1 wherein the animal is porcine and the dose is one which provides up to 300 ppm of chromium.

5. A nutritional composition of enhanced bioavailability for livestock, comprising a chromium complex of the formula:

6. The complex of claim 5 wherein “

X”

is monovalent.

7. The complex of claim 5 wherein “

X”

is selected from the group consisting of chloride, bromide, iodide, sulphate, phosphate, acetate and propionate.

8. The complex of claim 5 wherein “

R”

is selected so that the natural amino acid is one selected from the group consisting of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine and glycine.

9. The composition of claim 5 wherein the carrier is selected from the inert animal nutrition carrier group of natural salt, ground corn cobs, corn meal, and feathermeal.

10. A method of enhancing animal nutrition with chromium (III) 1:

3 complexes comprising;

administering to an animal in need thereof a small but nutrition enhancing effective amount of a chromium complex of the formula;

wherein “

R”

is an organic moiety normally present in a natural amino acid and “

X”

is a water soluble anion.

12. The method of claim 10 wherein the animal is bovine and the dose is from 0.03 mg/kg/body weight to 0.06 mg/kg/of body weight.

13. A method of forming 1:

3 chromium (III) polar solvent soluble chromium alpha amino acid complexes, comprising;

heating a water solution of a chromium (III) salt to near boiling;

adding to the heating mixture about three equivalents of an alpha amino acid;

continuing heating until the color changes from a dark red to purple; and

cooling and adjusting the pH to stabilize the complex.

14. The method of claim 13 wherein the heating is to a temperature within the range of 90°

C. to 95°

C.

15. The method of claim 14 wherein the pH is adjusted to within the range of from about 3.9 to about 4.0.

16. A nutritional composition of enhanced bioavailability for livestock, comprising a chromium complex of the formula:

17. The complex of claim 16 wherein “

X”

is monovalent.

18. The complex of claim 16 wherein “

X”

is selected from the group consisting of chloride, bromide, iodide, sulfate, phosphate, acetate and propionate.

19. The complex of claim 16 wherein “

R”

is selected so that the natural amino acid is one selected from the group consisting of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine and glycine.

20. The composition of claim 16 wherein the solvent is selected from water, ethanol, molasses or any other suitable solvent or mixture of suitable solvents.