Analyte sensor
First Claim
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1. An analyte sensor for detecting an analyte comprising:
- a first compartment adapted for introduction of said analyte;
a second compartment;
a barrier separating said first and second compartments, wherein said first compartment contains at least one component adapted to interact with said analyte, said interaction resulting in transport of a species across said barrier; and
a detector adapted to detect said transported species, or a derivative of said transported species, thereby detecting the presence of said analyte.
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Abstract
The present invention relates to analyte sensors including a first compartment adapted for introduction of a sample potentially containing the targeted analyte, and a second compartment separated from the first compartment by a barrier, wherein the analyte interacts with a component in the first compartment, or a polypeptide associated with the barrier, resulting in the transport of a species across the barrier, the transported species or a derivative thereof being detected by a detector, thereby indicating the presence of the analyte.
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Citations
49 Claims
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1. An analyte sensor for detecting an analyte comprising:
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a first compartment adapted for introduction of said analyte;
a second compartment;
a barrier separating said first and second compartments, wherein said first compartment contains at least one component adapted to interact with said analyte, said interaction resulting in transport of a species across said barrier; and
a detector adapted to detect said transported species, or a derivative of said transported species, thereby detecting the presence of said analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 37, 38, 39, 40, 41, 42, 43, 44)
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8. An analyte sensor for detecting an analyte comprising:
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a first compartment adapted for introduction of said analyte;
a second compartment;
a barrier separating said first and second compartments, said barrier comprising a biological membrane associated with a polypeptide, wherein said polypeptide is capable of participating in the transport of a species across said barrier upon interaction with said analyte, or a derivative of said analyte; and
a detector adapted to detect said transported species, or a derivative of said transported species, thereby indicating the presence of said analyte, wherein said detector (i) is not attached to said membrane, or (ii) is separated from said membrane by 50 nm or more. - View Dependent Claims (9, 10, 11, 12, 13)
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14. An analyte sensor for detecting an analyte comprising:
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a first compartment adapted for introduction of said analyte;
a second compartment;
a barrier separating said first and second compartments, said barrier comprising a biocompatible membrane having at least one layer comprising synthetic polymer, wherein said membrane is associated with at least one polypeptide, wherein said polypeptide is capable of participating in the transport of a species across said barrier upon interaction with said analyte, or a derivative of said analyte; and
a detector adapted to detect said transported species, or a derivative of said transported species, thereby indicating the presence of said analyte. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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45. An analyte sensor for detecting an analyte comprising:
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a first compartment adapted for introduction of said analyte;
a second compartment;
a barrier separating said first and second compartments, said barrier comprising a membrane associated with at least one polypeptide wherein said polypeptide is capable of participating in the transport of a detected species across said barrier and wherein said polypeptide is adapted to interact with said analyte or a derivative of said analyte whereby transport of said detected species is reduced;
and a detector adapted to detect said reduction, thereby detecting the presence of said analyte. - View Dependent Claims (46, 47, 48, 49)
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Specification