Continuous sulfatase inhibiting progestogen hormone replacement therapy
First Claim
1. A method of hormone replacement therapy comprising the step of administering continuously to a post-menopausal or estrogen deficient female in need of such therapy a combination of estrogen in an effective hormone replacement amount and a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount.
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Abstract
A method of hormone replacement therapy is disclosed comprising the step of administering continuously to a post-menopausal or estrogen deficient female in need of such therapy a combination of estrogen in an effective hormone replacement amount and a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount.
91 Citations
5 Claims
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1. A method of hormone replacement therapy comprising the step of administering continuously to a post-menopausal or estrogen deficient female in need of such therapy a combination of estrogen in an effective hormone replacement amount and a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount.
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2. A continuous hormone replacement therapy unit for administration to a post-menopausal or estrogen deficient female in need of such therapy comprising a cycle of separate dosage units adapted for successive daily oral administration for the length of the cycle, wherein said dosage units contain, in admixture with a pharmaceutically acceptable carrier, a combination of an estrogen in an effective hormone replacement amount and a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount.
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3. A continuous hormone replacement therapy unit for administration to a post-menopausal or estrogen deficient female in need of such therapy comprising one or more transdermal patches adapted for successive administration for the length of the cycle, wherein said transdermal patches of said unit collectively contain for a cycle of continuous administration a combination of an estrogen in an effective hormone replacement amount and a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount.
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4. A continuous hormone replacement therapy unit for administration to a post-menopausal or estrogen deficient female in need of such therapy comprising one or more vaginal rings adapted for successive administration for the length of the cycle, wherein said vaginal rings of said unit collectively contain for a cycle of continuous administration a combination of an estrogen in an effective hormone replacement amount and a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount.
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5. A continuous hormone replacement therapy unit for administration to a post-menopausal or estrogen deficient female in need of such therapy comprising a cycle of separate dosage units adapted for successive daily oral administration for the length of the cycle, wherein said dosage units contain, in admixture with a pharmaceutically acceptable carrier, a progestogen which is a potent sulfatase inhibiting progestogen in an amount which is both an effective endometrium protective amount and an effective breast protective amount when used in combination with an effective hormone replacement amount of an estrogen.
Specification