Bioactive agent release coating and controlled humidity method
First Claim
1. A method for controlling the rate of release of a bioactive agent from a coating composition provided in vivo, the method comprising the steps of:
- a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) applying the coating composition under conditions of controlled humidity to provide a corresponding controlled bioactive agent release profile in vivo.
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Abstract
A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
139 Citations
40 Claims
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1. A method for controlling the rate of release of a bioactive agent from a coating composition provided in vivo, the method comprising the steps of:
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a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) applying the coating composition under conditions of controlled humidity to provide a corresponding controlled bioactive agent release profile in vivo. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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21. A method for selecting an optimal bioactive agent release rate from a coated composition on a device to be positioned in vivo, the method comprising the steps of:
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a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component comprising at least one polymer selected from the group consisting of polyalkyl(meth)acrylates, polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) coating the composition on test device surfaces at a plurality of different humidity levels in order to provide corresponding release profiles, and evaluating the corresponding release profiles to determine a desired controlled humidity level.
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Specification