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Nucleic acid sequencing by signal stretching and data integration

  • US 20030232346A1
  • Filed: 06/17/2002
  • Published: 12/18/2003
  • Est. Priority Date: 06/17/2002
  • Status: Active Grant
First Claim
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1. ) A method comprising:

  • (a) separating a template nucleic acid into four samples, each sample to contain a different type of labeled nucleotide;

    (b) synthesizing labeled nucleic acid strands complementary in sequence to the template nucleic acids;

    (c) measuring the distances between the labeled nucleotides;

    (d) constructing a distance map for the labeled nucleic acid strands in each sample; and

    (e) assembling the distance maps into a nucleic acid sequence of the complementary strands.

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