Therapeutic polypeptides, nucleic acids encoding same, and methods of use
First Claim
1. An isolated polypeptide comprising the mature form of an amino acid sequenced selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39.
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Accused Products
Abstract
Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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Citations
45 Claims
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1. An isolated polypeptide comprising the mature form of an amino acid sequenced selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 29, 30, 31, 36, 37, 38, 39, 40)
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
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2. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39. - View Dependent Claims (41, 42, 43, 44, 45)
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
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3. An isolated polypeptide comprising an amino acid sequence which is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39.
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
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4. An isolated polypeptide, wherein the polypeptide comprises an amino acid sequence comprising one or more conservative substitutions in the amino acid sequence selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39.
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
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19. A method of treating a pathological state in a mammal, the method comprising administering to the mammal a polypeptide in an amount that is sufficient to alleviate the pathological state, wherein the polypeptide is a polypeptide having an amino acid sequence at least 95% identical to a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39 or a biologically active fragment thereof.
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
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20. An isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 121, 123, 125, 127, 129, 131 and SEQ ID NO;
2n-1, wherein n is an integer between 1 and 39. - View Dependent Claims (21, 25, 26, 27, 28, 32, 33, 34, 35)
- 121, 123, 125, 127, 129, 131 and SEQ ID NO;
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22. A nucleic acid molecule, wherein the nucleic acid molecule differs by a single nucleotide from a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 121, 123, 125, 127, 129, 131 and SEQ ID NO;
2n-1, wherein n is an integer between 1 and 39.
- 121, 123, 125, 127, 129, 131 and SEQ ID NO;
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23. An isolated nucleic acid molecule encoding the mature form of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
2n, wherein n is an integer between 1 and 39.
- 122, 124, 126, 128, 130, 132 and SEQ ID NO;
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24. An isolated nucleic acid molecule comprising a nucleic acid selected from the group consisting of SEQ ID NOs:
- 121, 123, 125, 127, 129, 131 and SEQ ID NOs;
2n-1, wherein n is an integer between 1 and 39.
- 121, 123, 125, 127, 129, 131 and SEQ ID NOs;
Specification