Methods of screening subjects for expression of soluble receptors of vascular endothelial growth factor (VEGF) for use in managing treatment and determining prognostic outcome
First Claim
Patent Images
1. A method comprising:
- (a) assaying a level of soluble VEGFR in a sample; and
(b) correlating said level with a level of membrane bound VEGFR in a subject from which said sample is derived.
0 Assignments
0 Petitions
Accused Products
Abstract
This invention relates generally to compounds and methods relating to detection of soluble VEGFR expression for generating prognostic criteria useful in establishing methods of treatment in cancer patients. In the method of the present invention, soluble VEGFR levels are utilized as a means by which cancer can be detected, efficacy of cancer therapies can be evaluated, prognosis of a subject can be predicted, and new anti-cancer therapies can be discovered.
-
Citations
21 Claims
-
1. A method comprising:
-
(a) assaying a level of soluble VEGFR in a sample; and
(b) correlating said level with a level of membrane bound VEGFR in a subject from which said sample is derived. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. A method for identifying cancer in a subject having elevated levels of membrane bound VEGFR, comprising:
-
(a) assaying a level of soluble VEGFR in a sample from the subject, (b) determining a level of membrane bound VEGFR in said subject, and (c) determining whether said subject has cancer based upon the level of soluble or membrane bound VEGFR in the subject. - View Dependent Claims (8, 9, 10)
-
-
11. A method for determining efficacy of a cancer treatment in a subject, comprising:
-
(a) assaying a level of soluble VEGFR in a sample from said subject prior to said cancer treatment, (b) assaying a level of soluble VEGFR in a sample from said subject during or after said cancer treatment; and
(c) determining efficacy of said treatment by comparing the level of soluble VEGFR in a sample from said subject prior to said cancer treatment to the level of soluble VEGFR in a sample from said subject during or after said cancer treatment. - View Dependent Claims (12, 13, 14, 15)
-
-
16. A method for predicting prognostic outcome of a cancer subject, comprising:
-
(a) assaying a level of soluble VEGFR in a sample from said subject, and (b) using the level of soluble VEGFR in the subject under conditions suitable to predict prognostic outcome of said subject.
-
-
17. A method for predicting prognostic outcome of a subject undergoing cancer treatment, comprising:
-
(a) assaying a level of soluble VEGFR in a sample from said subject prior to said cancer treatment, (b) assaying a level of soluble VEGFR in a sample from said subject during or after cancer treatment, and (c) predicting prognostic outcome of said subject undergoing said cancer treatment by comparing the level of soluble VEGFR in a sample from said subject prior to said cancer treatment to the level of soluble VEGFR in a sample from said subject during or after cancer treatment. - View Dependent Claims (18, 19, 20, 21)
-
Specification