Optically active substrates for examination of biological materials
First Claim
1. An optical apparatus for examination of biological material, comprising:
- an optical substrate having a surface comprising a dense array of micro-optical elements in close proximity to biological material being examined; and
a light source, a light detector, and optical elements for providing light from said light source to said biological material and from said biological material to said light detector, said optical elements including a lens arranged to provide light to and collect light from said dense array of micro-optical elements and said biological material, wherein said lens and said dense array of micro-optical elements are constructed to have optical properties that increase the number of photons interacting with said biological material and increase the number of photons collected by said lens after interaction with said biological material.
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Abstract
An optical apparatus for examination of biological material, a light source, a light detector and several optical elements for providing light from the light source to an optical substrate. The optical substrate having a surface comprising a dense array of micro-optical elements in close proximity to biological material being examined. The optical apparatus may include optical elements such as a lens that is arranged to provide light to and collect light from the dense array of micro-optical elements and the biological material. The lens and the dense array of micro-optical elements provide optical properties that increase the number of photons interacting with the biological material or increase the number of photons collected by the lens after interaction with the biological material.
95 Citations
48 Claims
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1. An optical apparatus for examination of biological material, comprising:
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an optical substrate having a surface comprising a dense array of micro-optical elements in close proximity to biological material being examined; and
a light source, a light detector, and optical elements for providing light from said light source to said biological material and from said biological material to said light detector, said optical elements including a lens arranged to provide light to and collect light from said dense array of micro-optical elements and said biological material, wherein said lens and said dense array of micro-optical elements are constructed to have optical properties that increase the number of photons interacting with said biological material and increase the number of photons collected by said lens after interaction with said biological material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An optical apparatus for examination of biological material, comprising:
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an optical substrate having a first surface and a second surface opposite to the first surface, the first surface comprising a dense array of micro-optical elements in close proximity to biological material being examined; and
a light source, a light detector, and optical elements for providing light from said light source to said biological material and from said biological material to said light detector, said dense array of micro-optical elements is constructed to increase the number of photons interacting with said biological material and increase the number of photons detected by said light detector after interaction with said biological material. - View Dependent Claims (36, 37, 38, 39, 40)
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41. An optically active substrate for use with an optical system constructed for examination of biological materials, comprising:
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an optical substrate having a first surface and a second surface opposite to the first surface; and
a dense array of micro-optical elements associated with said optical substrate and located in close proximity to biological material being examined, said dense array of micro-optical elements being constructed to have optical properties that increase the number of irradiation photons interacting with said biological material and increase the number of photons provided to an external optical system after interaction of said irradiation photons with said biological material. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48)
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Specification