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Treatment of sleeping disorders using CNS sleep target modulators

  • US 20030232839A1
  • Filed: 01/21/2003
  • Published: 12/18/2003
  • Est. Priority Date: 01/18/2002
  • Status: Abandoned Application
First Claim
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1. A method of treating a serotonin receptor associated disorder, comprising administering to a subject an effective amount of a therapeutic compound, such that the disorder is treated, wherein the therapeutic compound comprises the formula:

  • [EG]r-(SP2)q-[SR]-(SP1)n-[MR]wherein SR is a serotonin receptor antagonist, MR is a metabolite reducing moiety that reduces the formation of wake promoting metabolites, EG is an ester group that modifies the half-life of the therapeutic compound, SP1 and SP2 are spacer molecules, n, q, and r are independently 0 or 1, and r and q are 0 when MR is the ester group.

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