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Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs

  • US 20030232876A1
  • Filed: 04/16/2003
  • Published: 12/18/2003
  • Est. Priority Date: 08/16/1996
  • Status: Active Grant
First Claim
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1. A method of treating a patient for a migraine headache, comprising simultaneously administering to said patient:

  • (a) a 5-HT1B/1D agonist; and

    (b) a nonsteroidal anti-inflammatory drug having a pharmacokinetic half-life of at least 4 hours and a duration of action of at least 6 hours (“

    LA-NSAID”

    );

    wherein;

    said 5-HT1B/1D agonist and said LA-NSAID are administered to said patient orally after the onset of migraine symptoms; and

    the amount of said 5-HT1B/1D agonist and said LA-NSAID administered to said patient are sufficient to produce longer lasting efficacy compared to the administration of said 5-HT1B/1D agonist in the absence LA-NSAID or the administration of said LA-NSAID in the absence of said 5-HT1B/1D agonist.

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