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Optimization of transcutaneous active permeation of compounds through the synergistic use of ultrasonically generated mechanical abrasion of the skin, chemical enhancers and simultaneous application of sonophoresis, iontophoresis, electroporation, mechanical vibrations and magnetophoresis through single application devices

  • US 20030233085A1
  • Filed: 06/18/2002
  • Published: 12/18/2003
  • Est. Priority Date: 06/18/2002
  • Status: Abandoned Application
First Claim
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1. In a non-invasive method for enhancing the transcutaneous flux rate of an active permeant and either ionized form of compound or an unionized compound into an individual'"'"'s body surface targeting either local and systemic results, comprising the steps of (a) using in an area of wetted skin a mild abrasion of the skin surface via the scrubbing effect of ultrasound mechanical vibrations through a special applicator;

  • (b) contacting said area of the skin with a composition comprising an effective amount of said permeant along with compounds to be permeated;

    (c) enhancing the permeability of the selected area to the permeant by means of sonophoresis and applying simultaneously to said area iontophoresis, electroporation, mechanical vibrations and magnetophoresis for a time and with physical properties effective to enhance the transcutaneous flux rate into the body;

    the improvement comprising;

    initial skin scrubbing effect via ultrasound mechanical vibrations, simultaneous application of an active permeant and compounds along with sonophoresis, iontophoresis, electroporation, mechanical vibrations and magnetophoresis to an individual'"'"'s body surface area for a time and with physical properties effective to enhance the transcutaneous flux rate into the body, considerably lowering the required time of application and magnitude of physical parameters compared to those required if the chemical enhancers and compounds to be permeated were used alone;

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