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Microprocessors, devices, and methods for use in analyte monitoring systems

  • US 20030235817A1
  • Filed: 03/21/2003
  • Published: 12/25/2003
  • Est. Priority Date: 03/22/2002
  • Status: Abandoned Application
First Claim
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1. One or more microprocessors, comprising programming to control obtaining a measured charge signal over time, comprising a measured charge signal response curve specifically related to the amount or concentration of the glucose extracted from the subject, wherein said measured charge signal response curve comprises a kinetic region;

  • using (i) a mathematical model as presented in Eq. (3A) Q

    (t)
    =So+c1k1

    (1-

    -k1

    t
    )
    +c2k2

    (1-

    -k2

    t
    )
    (Eq.



    3


    A
    )
    wherein “

    Q”

    represents the charge, “

    t”

    represents the elapsed time, “

    So

    is a fitted parameter, “

    c1” and



    c2

    are pre-exponential terms that correspond to the electric current contribution at t=0 for first and second reactions, respectively, “

    k1” and



    k2

    are rate constants for the first and second reactions, respectively, and (ii) an error minimization method, to iteratively estimate values of parameters So, c1, c2, k1, and k2 using said model and error minimization method to fit a predicted response curve to said kinetic region of said measured charge signal response curve, wherein (a) the error minimization method provides a calculated error based on differences between kinetic regions of said predicted and measured charge signal response curves and (b) said estimating is iteratively performed until the calculated error between the predicted and measured charge signal response curves is minimized or until no further statistically significant change is seen in the calculated error, at which time iterative estimation of the parameters is stopped, said iterative estimation and error minimization results in estimated values of said parameters; and

    correlating 1/k2 with a glucose amount or concentration to provide a measurement of the amount or concentration of the glucose in the subject.

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