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Multiplexed analysis by chromatographic separation of molecular tags

  • US 20030235832A1
  • Filed: 11/08/2002
  • Published: 12/25/2003
  • Est. Priority Date: 06/21/2000
  • Status: Abandoned Application
First Claim
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1. A method for determining the presence or absence of one or more target compounds in a sample, the method comprising the steps of:

  • providing a plurality of binding compounds, such that there is at least one binding compound specific for each of the one or more target compounds, each binding compound having one or more molecular tags, each molecular tag being attached by a cleavable linkage, and the molecular tags of each binding compound being distinguishable from those of every other binding compound by one or more physical and/or optical characteristics;

    combining with the sample the plurality of binding compounds specific for the one or more target compounds such that in the presence of a target compound a complex is formed between such target compound and a binding compound specific therefor;

    cleaving the cleavable linkage of each binding compound forming such complex so that molecular tags are released; and

    chromatographically separating and identifying the released molecular tags by the one or more physical characteristics to determine the one or more target compounds in the sample.

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