Implantable or insertable medical devices for controlled delivery of a therapeutic agent
First Claim
1. A therapeutic-agent-releasing medical device comprising:
- (a) an implantable or insertable medical device;
(b) a release layer disposed over at least a portion of the implantable or insertable medical device, said release layer comprising a maleic anhydride polymer selected from (i) a maleic anhydride copolymer and (ii) a maleic anhydride graft polymer; and
(c) a therapeutic agent, said release layer regulating the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient.
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Accused Products
Abstract
The present invention is directed to novel implantable or insertable medical devices that provide controlled release of a therapeutic agent. According to an embodiment of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an implantable or insertable medical device; (b) a release layer disposed over at least a portion of the implantable or insertable medical device; and (c) a therapeutic agent. The release layer comprises a maleic anhydride polymer selected from (i) a maleic anhydride copolymer and (ii) a maleic anhydride graft polymer. The release layer regulates the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. The present invention is also directed to methods of forming the above implantable or insertable medical devices, methods of administering a therapeutic agent to a patient using such devices, and methods of modulating the release of therapeutic agent from such devices.
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Citations
50 Claims
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1. A therapeutic-agent-releasing medical device comprising:
- (a) an implantable or insertable medical device;
(b) a release layer disposed over at least a portion of the implantable or insertable medical device, said release layer comprising a maleic anhydride polymer selected from (i) a maleic anhydride copolymer and (ii) a maleic anhydride graft polymer; and
(c) a therapeutic agent, said release layer regulating the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 50)
- (a) an implantable or insertable medical device;
- 43. A method of modulating a rate of release of a therapeutic agent by a release layer that (a) is disposed over at least a portion of an implantable or insertable medical device and (b) comprises (i) a maleic anhydride polymer selected from a maleic anhydride copolymer and a maleic anhydride graft polymer and (ii) an additional polymer, said method comprising changing the composition of the release layer.
Specification