Method and device for anastomoses

• US 20030236518A1
• Filed: 05/15/2003
• Published: 12/25/2003
• Est. Priority Date: 05/15/2002
• Status: Active Grant

• Current Assignee: Rocky Mountain Biosystems, Inc.
• Original Assignee: Rocky Mountain Biosystems, Inc.
• Inventors: Marchitto, Kevin S., Flock, Stephen T.
• Granted Patent: US 7,588,565 B2
• Time in Patent Office: Days
• US Class Current: 606/27
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/085 Forceps, scissors
• CPC Class Codes: A61B 2018/00345 Vascular system
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00619 Welding

Abstract

Provided herein is a device for use in an anastomosis of tissue(s) comprising a biocompatible material and a means of applying radiofrequency energy or electrical energy to generate heat within said biocompatible material. The device also may be used to bond or fuse at two materials where at least one of the material is a tissue. Also provided are methods to anastomose tissue or to bond or to fuse these materials using these devices.

Claims

24. A device for bonding or fusing at least two materials, whereby at least one material is tissue, comprising:

a biocompatible material;

a means of applying radiofrequency energy or electrical energy to generate heat within said biocompatible material; and

a means of controlling output of the heat generated within said biocompatible material conducted to said materials to be bonded or to be fused.

25. The device of claim 24, wherein said biocompatible material conforms to tissue geometry.

26. The device of claim 24, wherein said biocompatible material is a liquid, a solid or a semi-solid.

27. The device of claim 24, wherein said biocompatible material comprises a protein, a biocompatible polymer, polymeric matrix substance, or a combination thereof.

28. The device of claim 27, wherein said protein is elastin, albumin, fibrin, collagen, or glycoprotein.

29. The device of claim 27, wherein said polymeric substance is hydrogel, agar or sol-gel.

31. The device of claim 24, wherein said means to apply electrical energy to said biocompatible material comprises at least one electrode in electrical contact with said biocompatible material.

32. The device of claim 24, wherein said means to apply radiofrequency energy to said biocompatible material comprises at least one induction coil proximate to said device, said induction coil(s) generating an oscillating magnetic field around said device.

33. The device of claim 32, further comprising a means of cooling said induction coil(s), said cooling means comprising:

a cooling fluid; and

a containment means for said cooling fluid.

34. The device of claim 33, wherein said cooling fluid is low viscosity mineral oil or water.

35. The device of claim 33, wherein said containment means is a glass envelope containing said cooling fluid and said induction coil(s) or copper tubing containing said cooling fluid.

36. The device of claim 32, further comprising a clamp-like instrument, said instrument comprising:

a first arm and a second arm, said first and second arms pivotally connected at the center, said first and second arms having a first end attached to said induction coils and a second end for manipulating and placing said induction coils proximate to said biocompatible material.

37. The device of claim 32, said induction coils further comprising a coating of a smooth non-adhering material.

38. The device of claim 37, wherein said non-adhering material comprises teflon, titanium or gold.

39. The device of claim 24, wherein the means of controlling output of heat conducted to said tissues comprises a conductive material in contact with said biocompatible material, said conductive material having a thermal history such that application of radiofrequency energy or electrical energy to said conductive material generates an estimable amount of heat.

40. The device of claim 39, wherein said conductive material is a metal wire, a metal particle, a ferromagnetic material, a paramagnetic material, a conducting polymer, an ionic molecule, a polar molecule or a conducting microsphere.

41. The device of claim 39, wherein said conductive material is an energy-absorbing material, said energy-absorbing material comprising conducting polystyrene microbeads, a colloidal metal, a conducting polymer, a strongly ionic molecule or a strongly polar molecule.

42. The device of claim 24, wherein said radiofrequency energy or said electrical energy is applied endoscopically.

43. A method for bonding or fusing two materials, whereby at least one is tissue, comprising the steps of:

positioning the device of claim 24 around said materials, said materials simultaneously in contact with the biocompatible material of said device and with each other;

applying radiofrequency energy or electrical energy to said biocompatible material;

generating heat within said biocompatible material; and

controlling output of heat to said materials to be bonded or to be fused via the heat controlling means of said device, said output of heat bonding said biocompatible material to said materials to be bonded or fusing said materials together.

44. The method of claim 43, wherein bonding of said biocompatible material to said materials or fusing said materials together results from molecular changes in said biocompatible material and in said materials.

30-1. The device of claim 30, wherein said pharmaceutical is an anti-coagulant, an antithrombotic, an antibiotic, a hormone, a steroidal antiinflammatory agent, a non-steroidal antiinflammatory agent, an anti-viral agent or an antifungal agent.