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Conjugates activated by cell surface proteases and therapeutic uses thereof

  • US 20040001801A1
  • Filed: 05/23/2002
  • Published: 01/01/2004
  • Est. Priority Date: 05/23/2002
  • Status: Abandoned Application
First Claim
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1. A conjugate, comprising a therapeutic agent and a peptidic substrate linked thereto optionally via a linker, wherein the peptidic substrate is proteolytically cleaved by a cell surface protease or a soluble, released or shed form thereof, to liberate the therapeutic agent, wherein the conjugate is not substantially cleaved by plasmin or prostate specific antigen (PSA).

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