Pharmaceutical tablet coating composition

• US 20040001884A1
• Filed: 06/21/2002
• Published: 01/01/2004
• Est. Priority Date: 06/21/2002
• Status: Abandoned Application

• Current Assignee: ISP Investments, Inc. (Ashland Global Holdings, Inc.)
• Original Assignee: ISP Investments, Inc. (Ashland Global Holdings, Inc.)
• Inventors: Moroni, .Antonio, Drefko, William J.
• Application Number:
  US10/177,516
• Publication Number:
  US 20040001884A1
• Time in Patent Office: Days
• US Class Current: 424/465
• CPC Class Codes: A61K 9/2813 Inorganic compounds
• CPC Class Codes: A61K 9/284 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A pharmaceutical tablet coating composition which is a synergistic combination of hydroxypropylmethyl cellulose and polyvinylpyrrolidone-vinyl acetate copolymer, providing coatings having high gloss, substantially no color fading for pigmented tablets and superior tensile strength.

Claims

1. A pharmaceutical tablet coating composition comprising a synergistic combination of (a) hydroxypropylmethylcellulose (HPMC), and (b) a polyvinylpyrrolidone (VP)-vinyl acetate (VA) copolymer.

2. A composition according to claim 1 wherein (b) is present in a weight amount of 5-45% in said composition.

3. A composition according to claim 2 wherein said amount is 10-20%.

4. A composition according to claim 1 wherein said copolymer has a 60:

40 wt. ratio of monomers.

5. A solution of the composition of claim 1.

6. A pharmaceutical tablet coated with the composition of claim 1.

7. A pharmaceutical tablet according to claim 6 whose coating has a high gloss, substantially no color fading, and a high tensile strength.