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Statistical algorithms for folding and target accessibility prediction and design of nucleic acids

  • US 20040002083A1
  • Filed: 01/22/2003
  • Published: 01/01/2004
  • Est. Priority Date: 01/29/2002
  • Status: Abandoned Application
First Claim
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1. A method of generating a sample of a predetermined number of probable secondary structures of an RNA sequence, comprising the steps of:

  • a) generating one or more partition functions of a fragment having one or more bases of the RNA sequence in accordance with a predetermined number of thermodynamics parameters; and

    b) generating secondary structures based on tracebacks using conditional probabilities computed with the partition function.

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