Analytical test cartridge; and, methods
First Claim
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1. A sample analysis cartridge comprising:
- (a) a liquid sample inlet;
(b) a main flow channel in fluid flow communication with the inlet;
(c) a titration cell arrangement including;
at least two titration spurs in fluid flow communication with the main flow channel; and
, a titration cell in each spur;
(d) a titration sensor arrangement including a sensor positioned in each titration cell in the titration cell arrangement; and
(e) a titration agent positioned in each titration cell of the titration cell arrangement, with a different amount of titration agent in at least two of the titration cells.
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Abstract
An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.
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Citations
21 Claims
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1. A sample analysis cartridge comprising:
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(a) a liquid sample inlet;
(b) a main flow channel in fluid flow communication with the inlet;
(c) a titration cell arrangement including;
at least two titration spurs in fluid flow communication with the main flow channel; and
, a titration cell in each spur;
(d) a titration sensor arrangement including a sensor positioned in each titration cell in the titration cell arrangement; and
(e) a titration agent positioned in each titration cell of the titration cell arrangement, with a different amount of titration agent in at least two of the titration cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of defining an analyte presence in a liquid sample;
- said method including steps of;
(a) directing a liquid sample into a plurality of spurs in fluid flow communication with a single main flow channel;
(b) titrating at least one of a selected analyte and a selected reagent in the liquid sample to a different degree in selected ones of the plurality of the spurs; and
,(c) calculating an amount of a analyte in the liquid sample based on a titration analysis determined by the step of titrating. - View Dependent Claims (18, 19, 20, 21)
- said method including steps of;
Specification