Alternate site gene therapy
First Claim
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1. A method for performing gene therapy on a selected section of a body lumen comprising:
- placing within a selected section of the body lumen a catheter including one or more expandable members for occluding sections of the body lumen proximal and/or distal to the selected section;
occluding sections of the body lumen proximal and/or distal to the selected section of the body lumen;
delivering a gene therapy composition into the selected section of the body lumen;
delivering ultrasound to the selected section of the body lumen for a period of time in the presence of the gene therapy composition under conditions where the ultrasound causes cavitation of cells in the selected section; and
transplanting the selected section of the body lumen into another region of the body.
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Abstract
A method is described for performing gene therapy at an alternate site when it is undesirable or impossible to perform gene therapy at the injured or diseased region. A gene therapy composition is administered using a catheter adapted to deliver ultrasound to facilitate uptake of the gene therapy composition into one or more cells at the alternate site. The treated section may then be transplanted to another region of the body which is diseased or injured.
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Citations
9 Claims
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1. A method for performing gene therapy on a selected section of a body lumen comprising:
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placing within a selected section of the body lumen a catheter including one or more expandable members for occluding sections of the body lumen proximal and/or distal to the selected section;
occluding sections of the body lumen proximal and/or distal to the selected section of the body lumen;
delivering a gene therapy composition into the selected section of the body lumen;
delivering ultrasound to the selected section of the body lumen for a period of time in the presence of the gene therapy composition under conditions where the ultrasound causes cavitation of cells in the selected section; and
transplanting the selected section of the body lumen into another region of the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification