Assay
First Claim
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1. A method for monitoring the immune system comprising a step of detecting modulation of Notch signalling.
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Accused Products
Abstract
A method for monitoring the immune system comprising monitoring the Notch signalling pathway.
4 Citations
73 Claims
- 1. A method for monitoring the immune system comprising a step of detecting modulation of Notch signalling.
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2. A method for monitoring the immune system comprising a step of detecting cleavage of the cleavable intracellular domain of Notch.
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3. A method for monitoring the immune system comprising a step of detecting interaction of Suppresser of Hairless (Su(H)), or homologues thereof, with Notch.
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4. A method for monitoring the immune system comprising a step of detecting interaction of Deltex, or homologues thereof, with Notch.
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5. A method for monitoring the immune system comprising a step of detecting interaction of Deltex, or homologues thereof, with Grb2.
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6. A method for monitoring the immune system comprising a step of detecting modulation of the Ras-JnK signalling pathway.
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7. A method for monitoring the immune system comprising a step of detecting cleavage of the cleavable extracellular domain of Delta.
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8. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting modulation of Notch signalling.
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9. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting cleavage of the cleavable intracellular domain of Notch.
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10. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting interaction of Suppresser of Hairless (Su(H)), or homologues thereof, with Notch.
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11. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting interaction of Deltex, or homologues thereof, with Notch.
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12. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting interaction of Deltex, or homologues thereof, with Grb2.
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13. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting modulation of the Ras-JnK signalling pathway.
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14. A method for detecting or monitoring T-cell activation or inactivation comprising a step of detecting cleavage of the cleavable extracellular domain of Delta.
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15. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting modulation of Notch signalling.
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16. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting cleavage of the cleavable intracellular domain of Notch.
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17. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting interaction of Suppresser of Hairless (Su(H)), or homologues thereof, with Notch.
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18. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting interaction of Deltex, or homologues thereof, with Notch.
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19. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting interaction of Deltex, or homologues thereof, with Grb2.
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20. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting modulation of the Ras-JnK signalling pathway.
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21. A method for detecting or monitoring immunological tolerance or activity comprising a step of detecting cleavage of the cleavable extracellular domain of Delta.
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22. A method for monitoring the efficacy of immunotherapy comprising a step of detecting modulation of Notch signalling.
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23. A method for monitoring the efficacy of immunotherapy comprising a step of detecting cleavage of the cleavable intracellular domain of Notch.
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24. A method for monitoring the efficacy of immunotherapy comprising a step of detecting interaction of Suppresser of Hairless (Su(H)), or homologues thereof, with Notch.
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25. A method for monitoring the efficacy of immunotherapy comprising a step of detecting interaction of Deltex, or homologues thereof, with Notch.
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26. A method for monitoring the efficacy of immunotherapy comprising a step of detecting interaction of Deltex, or homologues thereof, with Grb2.
- 27. A method for monitoring the efficacy of immunotherapy comprising a step of detecting modulation of the Ras-JnK signalling pathway.
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28. A method for monitoring the efficacy of immunotherapy comprising a step of detecting cleavage of the cleavable extracellular domain of Delta.
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29. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising a step of detecting modulation of Notch signalling.
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30. A method for detecting or monitoring Notch signalling comprising a step of detecting modulation of Notch signalling.
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31. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising a step of detecting cleavage of the cleavable intracellular domain of Notch.
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32. A method for detecting or monitoring Notch signalling comprising a step of detecting cleavage of the cleavable intracellular domain of Notch.
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33. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising a step of detecting interaction of Suppresser of Hairless (Su(H)), or homologues thereof, with Notch.
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34. A method for detecting or monitoring Notch signalling comprising a step of detecting interaction of Suppresser of Hairless (Su(H)), or homologues thereof, with Notch.
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35. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising a step of detecting interaction of Deltex, or homologues thereof, with Notch.
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36. A method for detecting or monitoring Notch signalling comprising a step of detecting interaction of Deltex, or homologues thereof, with Notch.
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37. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising a step of detecting interaction of Deltex, or homologues thereof, with Grb2.
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38. A method for detecting or monitoring Notch signalling comprising a step of detecting interaction of Deltex, or homologues thereof, with Grb2.
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39. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising a step of detecting modulation of the Ras-JnK signalling pathway.
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40. A method for detecting or monitoring Notch signalling comprising a step of detecting modulation of the Ras-JnK signalling pathway.
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41. A method for detecting or monitoring the reactivity of a T-cell to an antigen comprising the steps of:
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a. providing a T-cell in the presence of an antigen;
b. detecting modulation of Notch signalling within the T-cell; and
c. determining the reactivity of the T-cell to said antigen. - View Dependent Claims (42, 43, 44, 45, 46, 47)
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- 65. A kit for detecting or monitoring modulation of Notch signalling comprising a plurality of sequences or binding agents specific to nucleic acid or protein targets of Notch signalling.
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67. A nucleic acid or protein array consisting essentially of a plurality of sequences or binding agents specific to nucleic acid or protein targets of Notch signalling.
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70. The use of a detectable signal of Notch signalling for detecting or monitoring the reactivity of a T-cell to an antigen.
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71. The use of a detectable signal of Notch signalling for monitoring the immune system.
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72. The use of a detectable signal of Notch signalling for detecting or monitoring T-cell activation or inactivation.
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73. The use of a detectable signal of Notch signalling for detecting or monitoring immunological tolerance or activation.
Specification