Method and apparatus for temperature gradient microfluidics
First Claim
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1. An apparatus for providing a temperature gradient to a substrate, the apparatus comprising:
- a substrate having disposed thereon an architecture suitable for massively parallel chemical or biochemical processing;
first and second temperature elements disposed essentially parallel to each other wherein the first and second temperature elements are in thermal contact with the substrate and wherein the temperature gradient is essentially linear.
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Abstract
The present invention is an apparatus for providing a linear temperature gradient to an architecture suitable for massively parallel chemical or biochemical processing. The architecture is disposed on a substrate. The apparatus uses two temperature elements disposed essentially parallel to each other and in thermal contact with the substrate. When the temperature elements are held at different temperatures, a linear temperature gradient is formed in the substrate.
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Citations
47 Claims
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1. An apparatus for providing a temperature gradient to a substrate, the apparatus comprising:
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a substrate having disposed thereon an architecture suitable for massively parallel chemical or biochemical processing;
first and second temperature elements disposed essentially parallel to each other wherein the first and second temperature elements are in thermal contact with the substrate and wherein the temperature gradient is essentially linear. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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- 12. An apparatus for providing a temperature gradient to a plurality of channels, the apparatus comprising first and second temperature elements disposed essentially parallel to each other, a substrate in thermal contact with the temperature elements, and a plurality of channels disposed on the substrate.
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39. A method for providing a temperature gradient to a substrate, the method comprising:
- thermally contacting the substrate with first and second temperature elements that are essentially parallel to each other;
wherein the first temperature element is at a different temperature than the second temperature element;
wherein the substrate comprises an architecture suitable for massively parallel chemical or biochemical processing; and
wherein the temperature gradient is essentially linear. - View Dependent Claims (40, 41, 42)
- thermally contacting the substrate with first and second temperature elements that are essentially parallel to each other;
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43. A method of simultaneously determining the effect of temperature and at least one other parameter on the crystallization of an analyte, the method comprising:
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providing an apparatus, the apparatus comprising a substrate, the substrate comprising an architecture suitable for massively parallel chemical or biochemical processing, wherein the at least one other parameter can be varied as a function of position on the substrate first and second temperature elements disposed essentially parallel to each other wherein the first and second temperature elements are in thermal contact with the substrate, varying the at least one other parameter as a function of position on the substrate, and providing the first temperature element at a temperature that is different that the temperature of the second temperature element so that a linear temperature gradient is formed. - View Dependent Claims (44, 45, 46, 47)
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Specification