Pressure-pulse therapy device for treatment of deposits

• US 20040006288A1
• Filed: 04/28/2003
• Published: 01/08/2004
• Est. Priority Date: 10/29/2000
• Status: Abandoned Application

• Current Assignee: Medispec Ltd.
• Original Assignee: Medispec Ltd.
• Inventors: Harel, Alex, Spector, Avner
• Application Number:
  US10/415,293
• Publication Number:
  US 20040006288A1
• Time in Patent Office: Days
• US Class Current: 601/2
• CPC Class Codes: A61B 17/2256 with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means A61B17/2255 takes precedence

Abstract

A device, system and method for the generation of therapeutic acoustic shock waves for at least partially separating a deposit from a vascular structure. The shock waves may optionally be generated according to any mechanism which is known in the art, including but not limited to, spark gap technology, electromagnetic shock wave generation and piezoelectric technology for generating therapeutic pressure pulses. Examples of deposits which may be treated with the present invention include, but are not limited to, atherosclerotic plaques, any type of clot, and any type of thrombus or embolus. The vascular structure itself may be any such structure for conducting blood flow, including but not limited to arteries, veins and the aortic arch.

Claims

1. A system for treating at least a portion of a vascular structure of a subject, comprising:

(a) a shock wave generator for generating a shock wave for treating the portion of the vascular structure; and

(b) an imaging device for generating at least one image of the portion of the vascular structure to be treated, such that said shock wave is focused on the portion of the vascular structure according to a location determined from said at least one image.

2. The system of claim 1, further comprising:

(c) a locator module for determining a location of the portion according to said at least one image.

3. The system of claim 2, wherein said locator module is operated by a computational device for determining coordinates of said location of the portion.

4. The system of any of claims 1-3, wherein said imaging device operates at least partially according to at least one of x-ray imaging, MRI (magnetic resonance imaging) and CT (computerized tomography).

5. The system of any of claims 1-3, wherein said imaging device operates at least partially according to ultrasound.

6. The system of claim 5, wherein said imaging device operates at least partially according to ultrasound doppler.

7. The system of any of claims 1-3, wherein said imaging device is a non-real time imaging mechanism.

8. The system of claim 7, wherein said non-real time imaging mechanism is selected according to at least one of optimal distance from the subject and optimal geometric placement of said imaging device.

9. The system of claim 8, wherein said non-real time imaging mechanism is selected to prevent a significant delay between obtaining said at least one image and generating said shock wave.

10. The system of any of claims 2-9, further comprising:

(d) a positioner for positioning at least said shock wave generator according to said location of the portion as determined from said at least one image.

11. The system of claim 10, wherein said positioner automatically positions said shock wave generator.

12. The system of any of claims 1-11, further comprising:

(e) an initial imaging mechanism for at least initially determining an initial location of the portion.

13. The system of claim 12, wherein said initial imaging mechanism is angiography.

14. The system of claims 12 or 13, wherein said system features a positioner for positioning said imaging device according to said initial location of the portion.

15. The system of any of claims 1-14, wherein the portion of the vascular structure includes a deposit.

16. The system of claim 15, wherein said shock wave causes said deposit to become at least partially separated from the portion of the vascular structure.

17. The system of claims 15 or 16, wherein said deposit is one of a clot, thrombus and plaque.

18. The system of any of claims 1-17, wherein said shock wave is generated according to at least one of spark gap technology, piezo electric generation, generation by laser and electromagnetic generation.

19. A method for treating at least a portion of a vascular structure of a subject, comprising:

obtaining an image of the portion of the vascular structure;

determining an area of the portion of the vascular structure from said image;

focusing a shock wave on said area; and

treating at least a part of said area with said shock wave.

20. A method for treating at least a portion of a vascular structure of a subject, comprising:

determining an area of the portion of the vascular structure;

focusing a shock wave on said area; and

treating at least a part of said area with said shock wave.

21. A system for treating a tissue of a subject, comprising:

(a) a shock wave generator for generating a shock wave for treating the tissue; and

(b) an ultrasound doppler imaging device for generating at least one image of the tissue, such that said shock wave is focused on the tissue according to a location determined from said at least one image.

22. The system of claim 21, wherein said shock wave generator generates therapeutic acoustic shock waves and wherein treatment parameters are determined according to at least one of energy per pulse, frequency and number of pulses per length unit of the portion to be treated.

23. The system of claim 22, wherein energy per pulse is from about 50 to about 1500 Atm.

24. The system of claim 23, wherein energy per pulse is from about 500 to about 1000 Atm.

25. The system of any of claims 22-24, wherein frequency is from about 50 to about 500 pulses per minute.

26. The system of claim 25, wherein frequency is from about 100 to about 250 pulses per minute.

27. The system of any of claims 22-26, wherein number of pulses per length unit is from about 100 to about 5,000 per 1 cm.

28. The system of claim 27, wherein number of pulses per length unit is from about 300 to about 800 pulses per 1 cm.

29. The system of any of claims 22-28, wherein at least about 500 pulses are applied to an edge of the portion.

30. The system of claim 29, wherein less than about 1000 pulses are applied.

31. A system for treating at least a portion of a deposit on a vascular structure of a subject, comprising:

(a) a shock wave generator for generating a shock wave for treating the deposit on the portion of the vascular structure;

(b) an imaging device for generating at least one image of the portion of the vascular structure to be treated, such that said shock wave is focused on the portion of the vascular structure according to a location determined from said at least one image; and

(c) a block removal mechanism for removing the deposit after treatment by said shock wave generator.

32. The system of claim 31, wherein said block removal mechanism includes a catheter.

33. The system of claims 31 or 32, wherein said block removal mechanism includes drug treatment.

34. The system of any of claims 31-33, wherein said block removal mechanism is at least partially provided through the operation of at least one of minimal invasive surgery techniques and instruments.

35. A method for treating at least a portion of a deposit on a vascular structure of a subject, comprising:

generating at least one image of the portion of the vascular structure to be treated;

focusing said shock wave on the portion of the vascular structure according to a location determined from said at least one image;

generating a shock wave for treating the deposit on the portion of the vascular structure; and

removing the deposit after treatment by said shock wave generator.