Method for providing natural therapeutic agents with high therapeutic index
First Claim
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1. A method for providing a therapeutic agent comprising the steps of:
- a) providing a reference molecule having a therapeutic index;
b) selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene or related gene or both and having therapeutic potential;
c) determining the therapeutic index of said at least one polypeptide selected in step b); and
d) retaining as a therapeutic agent, at least one polypeptide selected in step b) whose therapeutic index, as determined in step c), is higher than the therapeutic index of the reference molecule.
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Abstract
Methods for identifying and providing new therapeutic agent(s) by selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene having a therapeutic potential; determining the therapeutic index of the selected polypeptide(s) and retaining as therapeutic agent(s) those polypeptide(s) whose therapeutic index is higher than that of a reference agent.
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Citations
22 Claims
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1. A method for providing a therapeutic agent comprising the steps of:
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a) providing a reference molecule having a therapeutic index;
b) selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene or related gene or both and having therapeutic potential;
c) determining the therapeutic index of said at least one polypeptide selected in step b); and
d) retaining as a therapeutic agent, at least one polypeptide selected in step b) whose therapeutic index, as determined in step c), is higher than the therapeutic index of the reference molecule. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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3. A method for providing a therapeutic agent comprising the steps of:
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a) selecting at least one polypeptide encoded by a natural allelic variant of a gene selected from the group consisting of one preselected gene with therapeutic potential, one related gene thereof and a combination thereof;
b) determining a therapeutic index for each polypeptide selected in step a);
c) identifying a polypeptide selected in step a) whose therapeutic index, as determined in step b), is higher than a therapeutic index of reference;
d) retaining as a therapeutic agent, the polypeptide identified in step c), which has the highest or second highest therapeutic index. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification