Compositions and methods for dosing liposomes of certain sizes to treat or prevent disease
First Claim
1. A method for preventing, treating, or managing a disease or bodily condition comprising administering liposomes between 50 mg/kg and 300 mg/kg in single or divided doses, said liposomes comprising phospholipids and an aqueous layer, said liposomes having an average diameter between about 50 nm and 250 nm.
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Accused Products
Abstract
The present invention relates to pharmaceutical compositions comprising liposomes and methods of using such liposomes to prevent, treat, or manage a variety of diseases and/or bodily conditions. The liposomes may comprise large unilamellar vesicles (LUVs) alone or in combination with multilamellar vesicles (MLVs), small unilamellar vesicles (SUVs), or other therapeutics. The invention relates to liposomes having certain diameters administered to patients using specific doses and/or dosing regimens.
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Citations
61 Claims
- 1. A method for preventing, treating, or managing a disease or bodily condition comprising administering liposomes between 50 mg/kg and 300 mg/kg in single or divided doses, said liposomes comprising phospholipids and an aqueous layer, said liposomes having an average diameter between about 50 nm and 250 nm.
- 56. A method of reducing cholesterol in peripheral tissue while reducing or avoiding adverse effects associated with liposome therapy which comprises administering to a patient in need thereof a dose of between 100 mg/kg to 200 mg/kg of liposomes having an average particle size between 50 nm and 250 nm.
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57. A method of preventing or treating a disease or disorder associated with abnormal cholesterol levels which comprises administering to a patient in need thereof doses from 100 mg/kg to 200 mg/kg of liposomes, said administration being made in a single or multiple dose every 7 or more days.
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60. A method of reducing cholesterol in a diseased human which comprises administering to said human liposomes in a dose of 100 mg/kg to 200 mg/kg every 4 or more days, said liposomes having an average diameter of between 50 nm and 250 nm.
Specification