Obesity controlling method

• US 20040009224A1
• Filed: 08/13/2003
• Published: 01/15/2004
• Est. Priority Date: 08/11/2000
• Status: Active Grant

• Current Assignee: Temple University of The Commonwealth System of Higher Education
• Original Assignee: Temple University of The Commonwealth System of Higher Education
• Inventors: Miller, Larry S.
• Granted Patent: US 7,608,578 B2
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61F 5/0079 Pyloric or esophageal obstructions
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding stomach emptying and producing a feeling of satiation in the patient. The method may be supplemental and augmented by inducing flacid paralysis of the stomach by injecting botulinum toxin into the muscle tissue of the antrum or fundus of the stomach.

Claims

1. A method of treating obesity comprising injecting a bio-compatible bulking material submucosally or intramuscularly into the pyloric area of the stomach in an amount sufficient to cause the lumen of pylorus to narrow and slow gastric emptying.

2. The method of claim 1 wherein said bio-compatible bulking material comprises collagen, fibrin, or elastin.

3. The method of claim 2 wherein said bio-compatible bulking material comprises collagen in one of the following forms:

fibrillar, non-fibrillar, crosslinked, non-crosslinked, aqueous, or denatured gelatin.

4. The method of claim 1 wherein said bio-compatible bulking material comprises, Teflon paste, a synthetic polymeric hydrogel, a glycoaminoglycan, a proteoglycan, or microbeads suspended in a biological fluid lubricant.

5. The method of claim 1 wherein said bio-compatible bulking material is injected through a needle inserted through a biopsy channel of an endoscope inserted into the stomach.

6. The method of claim 5 comprising supplemental laser treatment of the pylorus wherein a laser of thermal device is placed through the biopsy channel and the pylorus is scarred with said device to further narrow the lumen.

7. The method of claim 5 comprising supplemental closing of the pylorus wherein a sewing device is placed through the biopsy channel and the pylorus is sewn with said device to further narrow the lumen.

8. The method of claim 5 comprising inducing supplemental flaccid paralyses of the stomach wherein a needle is placed through the biopsy channel and botulinum toxin is injected into the muscles of the fundus.

9. The method of claim 5 comprising inducing supplemental flaccid paralyses of the stomach wherein a needle is placed through the biopsy channel and botulinum toxin is injected into the antrum of the stomach.