Bowel cleansing composition

• US 20040009236A1
• Filed: 07/15/2002
• Published: 01/15/2004
• Est. Priority Date: 07/15/2002
• Status: Active Grant

• Current Assignee: George M. Halow
• Original Assignee: George M. Halow
• Inventors: Halow, George M.
• Granted Patent: US 8,361,452 B2
• Time in Patent Office: Days
• US Class Current: 424/606
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention provides compositions for rapid bowel cleansing comprising a mixture of polyethylene glycol and sodium phosphate(s). The compositions are particularly useful for preparing the bowel prior to surgery or diagnostic procedures such as colonoscopies. The invention further comprises methods for cleansing the bowel using these compositions, and bowel cleansing kits comprising these compositions.

Claims

1. A dry bowel cleansing composition comprising from about 20 to 40% by wt. of a phosphate powder comprising disodium phosphate or an admixture of disodium phosphate and sodium monophosphate and from about 60 to 80% by wt. water-soluble polyethylene glycol (PEG), based on the combined weight of PEG and phosphate.

2. The composition of claim 1, wherein the sodium phosphate powder is dibasic sodium phosphate.

3. The composition of claim 1, wherein the sodium phosphate powder is a mixture of dibasic sodium phosphate and monobasic sodium phosphate.

4. The composition of claim 1, wherein the composition contains from about 20 to 30% by wt. sodium phosphate powder and from about 70 to 80% by wt. PEG, based on the combined weight of PEG and phosphate.

5. The composition of claim 2, wherein the composition contains from about 20 to 30% by wt. sodium phosphate powder and from about 70 to 80% by wt. PEG, based on the combined weight of PEG and phosphate.

6. The composition of claim 3, wherein the composition contains from about 20 to 30% by wt. sodium phosphate powder and from about 70 to 80% by wt. PEG, based on the combined weight of PEG and phosphate.

7. The composition of claim 1, wherein the composition contains from about 20 to 25% by wt. sodium phosphate powder and from about 75 to 80% by wt. PEG, based on the combined weight of PEG and phosphate.

8. The composition of claim 2, wherein the composition contains from about 20 to 25% by wt. sodium phosphate powder and from about 75 to 80% by wt. PEG, based on the combined weight of PEG and phosphate.

9. The composition of claim 3, wherein the composition contains from about 20 to 25% by wt. sodium phosphate powder and from about 75 to 80% by wt. PEG, based on the combined weight of PEG and phosphate.

10. The composition of claim 1, further comprising a bowel stimulant.

11. The composition of claim 10, wherein the bowel stimulant is bisacodyl.

12. The composition of claim 10, wherein the bowel stimulant is Cascara sagrada.

13. A single dosage of a dry bowel cleansing composition comprising from about 10 grams to about 30 grams of a phosphate powder comprising dibasic sodium phosphate or an admixture of dibasic sodium phosphate and monobasic sodium phosphate, and from about 45 grams to 70 grams water-soluble PEG.

14. A single dosage of the composition of claim 13, comprising from about 15 grams to about 25 grams of phosphate powder and from about 55 grams to 65 grams water soluble PEG.

15. A single dosage of the composition of claim 14, comprising from about 15 grams to about 20 grams of phosphate powder and from about 58 grams to 63 grams water-soluble PEG.

16. A method for cleansing the bowel comprising orally administering at least one dosage according to claim 13, dissolved in an aqueous medium.

17. A method for cleansing the bowel comprising orally administering at least one dosage according to claim 14, dissolved in an aqueous medium.

18. A method for cleansing the bowel comprising orally administering at least one dosage according to claim 15, dissolved in an aqueous medium.

19. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage according to claim 13, dissolved in an aqueous medium, within the 36 hour period preceding the procedure.

20. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage according to claim 14, dissolved in an aqueous medium, within the 36 hour period preceding the procedure.

21. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage according to claim 15, dissolved in an aqueous medium, within the 36 hour period preceding the procedure.

22. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage of a composition according to claim 13, dissolved in an aqueous medium, within the 36 hour period preceding the procedure and while maintaining a clear liquid diet.

23. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage of a composition according to claim 14, dissolved in an aqueous medium, within the 36 hour period preceding the procedure and while maintaining a clear liquid diet.

24. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage of a composition according to claim 15, dissolved in an aqueous medium, within the 36 hour period preceding the procedure and while maintaining a clear liquid diet.

25. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering on the day before the procedure at least two dosages of a composition according to claim 13, each dissolved in or taken with at least one quart of an aqueous medium.

26. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering on the day before the procedure at least two dosages of a composition according to claim 14, each dissolved in or taken with at least one quart of an aqueous medium.

27. A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering on the day before the procedure at least two dosages of a composition according to claim 15, each dissolved in or taken with at least one quart of an aqueous medium.

28. A bowel cleansing kit comprising one or more dosages of a dry composition according to claim 13, one or more clear liquid diet powders, and optionally a flavor pack.

29. A bowel cleansing kit comprising one or more dosages of a dry composition according to claim 14, one or more clear liquid diet powders, and optionally a flavor pack.

30. A bowel cleansing kit comprising one or more dosages of a dry composition according to claim 15, one or more clear liquid diet powders, and optionally a flavor pack.