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Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury

  • US 20040009593A1
  • Filed: 04/04/2003
  • Published: 01/15/2004
  • Est. Priority Date: 07/11/2002
  • Status: Active Grant
First Claim
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1. A differentiated cell population as part of a system for generating glial cells, wherein at least ˜

  • 80% of cells in the differentiated cell population are progeny of primate pluripotent stem (pPS) cells, and have at least one of the following properties;

    they stain with 04 or RIP antibody, or with antibody specific for NG2 or galactocerebroside (GalC);

    they express GaIC or MBP after being cultured for 3 days on poly-L-lysine and laminin in the absence of mitogens;

    or following implantation in or around the spinal cord in contusion-injured rats, they cause improvement in overground locomotion;

    and wherein the system further comprises the line of pPS cells from which the differentiated cells were produced.

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