Minicell display and products therefrom
First Claim
1. An isolated peptide of 100 amino acids or less comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 40, SEQ ID NO;
45, SEQ ID NO;
46, SEQ ID NO;
47, SEQ ID NO;
48, SEQ ID NO;
52, SEQ ID NO;
53, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
33, SEQ ID NO;
34, SEQ ID NO;
37, SEQ ID NO;
38, SEQ ID NO;
39, SEQ ID NO;
41, SEQ ID NO;
42, SEQ ID NO;
49, SEQ ID NO;
50, SEQ ID NO;
51, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23, SEQ ID NO;
24, SEQ ID NO;
25, SEQ ID NO;
26, SEQ ID NO;
27, SEQ ID NO;
28, SEQ ID NO;
29, SEQ ID NO;
31, SEQ ID NO;
32, SEQ ID NO;
7, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
19, SEQ ID NO;
35, SEQ ID NO;
36, SEQ ID NO;
54, SEQ ID NO;
55, SEQ ID NO;
56, and SEQ ID NO;
57.
1 Assignment
0 Petitions
Accused Products
Abstract
A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process. The method, based on the small, anucleate minicell, has increased versatility in generating unique sequences to screen as well as increasing the size of the peptides to be screened. In vivo mutagenesis, at the level of protein synthesis, as well as DNA replication, increases diversification of the library to be screened and therefore substantially increases the number of potential peptides that can modulate a particular biological response or mechanism. A number of representative peptides have been generated using this methodology and demonstrated to have desirable biological and pharmaceutical activities.
9 Citations
27 Claims
-
1. An isolated peptide of 100 amino acids or less comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 40, SEQ ID NO;
45, SEQ ID NO;
46, SEQ ID NO;
47, SEQ ID NO;
48, SEQ ID NO;
52, SEQ ID NO;
53, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
33, SEQ ID NO;
34, SEQ ID NO;
37, SEQ ID NO;
38, SEQ ID NO;
39, SEQ ID NO;
41, SEQ ID NO;
42, SEQ ID NO;
49, SEQ ID NO;
50, SEQ ID NO;
51, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23, SEQ ID NO;
24, SEQ ID NO;
25, SEQ ID NO;
26, SEQ ID NO;
27, SEQ ID NO;
28, SEQ ID NO;
29, SEQ ID NO;
31, SEQ ID NO;
32, SEQ ID NO;
7, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
19, SEQ ID NO;
35, SEQ ID NO;
36, SEQ ID NO;
54, SEQ ID NO;
55, SEQ ID NO;
56, and SEQ ID NO;
57. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
- 40, SEQ ID NO;
Specification