Medicament respiratory delivery device and cartridge

• US 20040011356A1
• Filed: 05/10/2002
• Published: 01/22/2004
• Est. Priority Date: 01/12/2001
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Sullivan, Vincent
• Granted Patent: US 6,782,887 B2
• Time in Patent Office: Days
• US Class Current: 128/200.14
• CPC Class Codes: A61M 11/003 by passing the aerosol trough sieves or filters
• CPC Class Codes: A61M 11/008 by squeezing, e.g. using a flexible bottle or a bulb
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0033 Details of the piercing or cutting means
• CPC Class Codes: A61M 15/0068 Indicating or counting the number of dispensed doses or of remaining doses
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61M 2205/075 Bulb type
• CPC Class Codes: B05B 11/061 characterised by the means producing the gas or vapour pressure
• CPC Class Codes: B05B 11/062 designed for spraying particulate material

Abstract

A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing, such that fluid delivered to the inlet ruptures the membranes, entrains medicament contained within the cartridge passage which is delivered to the patient'"'"'s respiratory system through the outlet.

Claims

1. A medicament respiratory delivery device, comprising:

a housing comprised of two opposed thermoformed bonded thermoplastic sheets, said sheets having formed therebetween a chamber, an inlet communicating with said chamber, a pressure actuator having an outlet communicating with said inlet of said chamber and an outlet communicating with said chamber opposite said inlet of said chamber; and

a medicament cartridge in said chamber encapsulated by said sheets, said medicament cartridge including a body having opposed first and second ends, a passage extending through said body through said opposed first and second ends aligned with said inlet and outlet of said housing, a medicament in said passage, and burstable membranes covering said first and second ends of said passage, whereby delivery of fluid under pressure from said pressure actuator through said inlet of said housing ruptures said burstable membranes and delivers said medicament to said outlet of said housing, wherein said delivered medicament has a fine particle fraction of at least 18.5%.

2. The medicament respiratory delivery device as defined in claim 1, wherein said pressure actuator formed between said sheets is collapsible and generally spherical and symmetrical relative to said outlet of said collapsible pressure actuator.

3. The medicament of respiratory delivery device as defined in claim 1, wherein the medicament is albuterol sulfate.

4. The medicament of respiratory delivery device as defined in claim 3, wherein the albuterol sulfate is in the amount of less than 400 μ

g/dose.

5. The medicament of respiratory delivery device as defined in claim 3, wherein the albuterol sulfate is in the amount of less than 200 μ

g/dose.

6. The medicament of respiratory delivery device as defined in claim 3, wherein the albuterol sulfate is in the amount of less than 100 μ

g/dose.

7. A method of delivering a medicament to the respiratory system of a user, comprising the following steps:

providing a medicament respiratory delivery device including a cartridge having opposed inlet and outlet ends, a passage containing medicament extending through said cartridge and through said inlet and outlet ends, a thin burstable membrane having a burst pressure of between 1.2 and 10 atmospheres sealing said passage at said outlet end of said cartridge, and a manually acitivated fluid delivery device communicating with said inlet end of said cartridge; and

i activating said manually activated fluid delivery device to deliver fluid under pressure to said inlet end of said cartridge, rupturing said thin burstable membrane, entraining said medicament in said fluid, and delivering said medicament to the respiratory system of the user, wherein said delivered medicament has a fme particle fraction of at least 18.5%.

8. The method of delivering a medicament to the respiratory system of a user as defined in claim 7, wherein the medicament is albuterol sulfate.

9. The method of delivering a medicament to the respiratory system of a user as defined in claim 8, wherein the albuterol sulfate is in the amount of less than 400 μ

g/dose.

10. The method of delivering a medicament to the respiratory system of a user as defined in claim 8, wherein the albuterol sulfate is in the amount of less than 200 μ

g/dose.

11. The method of delivering a medicament to the respiratory system of a user as defined in claim 8, wherein the albuterol sulfate is in the amount of less than 100 μ

g/dose.