Measurement of an analyte concentration in a scattering medium
First Claim
1. A method for measuring the concentration of an analyte in a scattering medium, the method comprising the steps of:
- illuminating a sample containing said analyte with broad spectrum radiation;
detecting an amount of transmitted, transflected, or reflected radiation from the sample with a detector;
associating a vector in a vector space with the amount of transmitted, transflected, or reflected radiation;
determining a correction vector from a standard in a non-scattering medium; and
utilizing said correction vector and said vector associated with the amount of transmitted, transflected, or reflected radiation to identify and to obtain the concentration of the analyte in the scattering medium.
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Abstract
A non-invasive detection method for glucose and other constituents of interest in a sample is described. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing the spectrophotometers used in other non-invasive near infrared detection methods. A plurality of detection units are used, each covering a broad region of the detected spectrum, paralleling color perception and colorimetry. In some circumstances, a neural net is used for analysis, allowing the system to learn. Analyte concentrations in scattering mediums can be obtained by calibrating the results with in vitro measurements.
15 Citations
38 Claims
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1. A method for measuring the concentration of an analyte in a scattering medium, the method comprising the steps of:
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illuminating a sample containing said analyte with broad spectrum radiation;
detecting an amount of transmitted, transflected, or reflected radiation from the sample with a detector;
associating a vector in a vector space with the amount of transmitted, transflected, or reflected radiation;
determining a correction vector from a standard in a non-scattering medium; and
utilizing said correction vector and said vector associated with the amount of transmitted, transflected, or reflected radiation to identify and to obtain the concentration of the analyte in the scattering medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for measuring the concentration of an analyte in a scattering medium, the system comprising:
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a light source for illuminating a sample containing said analyte with broad spectrum radiation;
a detector for detecting an amount of transmitted, transflected, or reflected radiation from the sample;
a generator for generating a vector in a vector space that is associated with the amount of transmitted, transflected, or reflected radiation; and
an analyzer for determining a correction vector from a standard in a non-scattering medium, and for utilizing said correction vector and said vector associated with the amount of transmitted, transflected, or reflected radiation to identify and to obtain the concentration of the analyte in the scattering medium. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification