Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use
First Claim
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1. An intraocular implant composition comprising a lipophilic compound having a molecular weight of 150-4000 and a pharmaceutically effective amount of a drug, but lacking a polymeric ingredient and an organic solvent that is miscible with or dispersible in water, wherein the composition is solid or semi-solid at temperatures ≦
- 37°
C. and the lipophilic compound is of the formula
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Abstract
Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient.
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Citations
25 Claims
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1. An intraocular implant composition comprising a lipophilic compound having a molecular weight of 150-4000 and a pharmaceutically effective amount of a drug, but lacking a polymeric ingredient and an organic solvent that is miscible with or dispersible in water, wherein the composition is solid or semi-solid at temperatures ≦
- 37°
C. and the lipophilic compound is of the formula - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- 37°
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21. A method of delivering an ophthalmically acceptable drug to the eye comprising the steps of
(a) preparing an intraocular implant composition comprising a lipophilic compound having a molecular weight of 150-4000 and a pharmaceutically effective amount of a drug, but lacking a polymeric ingredient and an organic solvent that is miscible with or dispersible in water, wherein the composition is solid or semi-solid at temperatures ≦ - 34°
C. and the lipophilic compound is of the is formula
whereinR1 is —
H, —
OH, —
COOH, —
CnH2n+1-2m, —
COOCnH2n+1-2m, —
COO(CH2CH2O)nCH2CH2OH, —
CH2R3, orR2, R3 and R4 are independently —
H, —
OH, —
COOH, —
CnH2n+1-2m, —
OOCCnH2n+1-2m, —
COOCnH2n+1-2m, —
COO(CH2CH2O)nCH2CH2OH, —
CnH2n+1-2mCOO(CH2CH2O)nCH2CH2OH, —
OOCCnH2n+1-2mCOOCn′
H2n+1-2m′
, —
COO−
Na+, —
COO−
K+, —
SO3H, —
SO3−
Na+, —
SO3−
K+, —
NH2, —
Cl,n, n′ and
n″
are independently 0-50; and
m, m′ and
m″
are independently 0-10; and
(b) implanting the composition prepared in step (a) in the eye. - View Dependent Claims (22, 23, 24, 25)
- 34°
Specification