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High density parallel printing of microarrays

  • US 20040014102A1
  • Filed: 05/06/2003
  • Published: 01/22/2004
  • Est. Priority Date: 02/22/2000
  • Status: Abandoned Application
First Claim
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1. A method for printing a microarray comprising:

  • providing a substrate having a substrate surface;

    providing at least one probe reservoir;

    providing at least one capillary bundle comprising a plurality of individual capillaries;

    each of the capillaries having an input end and an output end;

    wherein the output ends of the individual capillaries are secured in a print head such that the output ends of the capillaries are substantially coplanar in an array in a facet of the print head such that the capillaries have a capillary pitch P;

    placing the input ends of the individual capillaries in fluid communication with at least one probe reservoir;

    transporting probe from at least one probe reservoir to the output ends of the capillaries; and

    printing an array of probes on the substrate such that the printed probes have a probe pitch of approximately PIN;

    wherein N is an integer greater than one.

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