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Active variants of FGF with improved specificity

  • US 20040014658A1
  • Filed: 04/29/2003
  • Published: 01/22/2004
  • Est. Priority Date: 10/31/2000
  • Status: Active Grant
First Claim
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1. An active variant of a fibroblast growth factor having at least one mutation in the beta 8 beta 9 loop, wherein said FGF variant having enhanced specificity for one receptor subtype compared to the corresponding wild type FGF, by decreasing the biological activity mediated by at least one receptor subtype while retaining the activity mediated through another receptor subtype.

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