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Single-chain antagonist polypeptides

  • US 20040014948A1
  • Filed: 05/23/2003
  • Published: 01/22/2004
  • Est. Priority Date: 10/07/1999
  • Status: Abandoned Application
First Claim
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1. A single-chain oligomeric polypeptide which binds to an extracellular ligand-binding domain of a cellular receptor of a type requiring binding of an oligomeric ligand to two or more receptor subunits to be activated, the polypeptide comprising at least three receptor-binding sites of which at least one is capable of binding to a ligand-binding domain of the cellular receptor and at least one is incapable of effectively binding to a ligand-binding domain of the cellular receptor, whereby the single-chain oligomeric polypeptide is capable of binding to the receptor, but incapable of activating the receptor.

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