Implantable devices with invasive and non-invasive reversible infusion rate adjustability
First Claim
Patent Images
1. A pump for delivering a pharmaceutical agent, comprising:
- a pump engine;
a piston;
a pharmaceutical agent compartment configured to enclose a volume of pharmaceutical agent and the piston, the pharmaceutical agent compartment being configured such that when the piston is acted upon by the pump engine, the piston moves within the pharmaceutical agent compartment and delivers the pharmaceutical agent, and a rate adjustment assembly configured to enable a selective and reversible increase or decrease of a delivery rate of the pharmaceutical agent.
1 Assignment
0 Petitions
Accused Products
Abstract
An implantable pump for delivering a pharmaceutical agent includes a pump engine, a piston, a pharmaceutical agent compartment and a rate adjustment assembly. The pharmaceutical agent compartment is configured to enclose a volume of pharmaceutical agent and the piston. When the piston is acted upon by the pump engine, the piston moves within the pharmaceutical agent compartment along a substantially circular path and delivers the pharmaceutical agent. The rate adjustment assembly is configured to enable a selective and reversible increase or decrease of the delivery rate of the pharmaceutical agent.
68 Citations
19 Claims
-
1. A pump for delivering a pharmaceutical agent, comprising:
-
a pump engine;
a piston;
a pharmaceutical agent compartment configured to enclose a volume of pharmaceutical agent and the piston, the pharmaceutical agent compartment being configured such that when the piston is acted upon by the pump engine, the piston moves within the pharmaceutical agent compartment and delivers the pharmaceutical agent, and a rate adjustment assembly configured to enable a selective and reversible increase or decrease of a delivery rate of the pharmaceutical agent. - View Dependent Claims (2, 3, 4, 5)
-
-
6. A method of delivering a pharmaceutical agent, comprising steps of:
-
implanting a pump into the patient, the pump including a pump engine, a piston, a pharmaceutical agent compartment configured to enclose a volume of pharmaceutical agent and the piston, the pharmaceutical agent compartment being configured such that when the piston is acted upon by the pump engine, the piston moves within the pharmaceutical agent compartment and delivers the pharmaceutical agent, and a rate adjustment assembly configured to enable a selective and reversible increase or decrease of a delivery rate of the pharmaceutical agent;
manipulating the rate adjustment assembly to selectively increase or decrease the delivery rate of the pharmaceutical agent. - View Dependent Claims (7, 8, 9, 10, 11)
-
-
12. An osmotic pump, comprising:
-
an osmotic engine;
a pump housing enclosing the osmotic engine and defining a space adapted to contain a volume of pharmaceutical agent, and a rate adjustment module configured to enable a selective and reversible increase or decrease of a delivery rate of the pharmaceutical agent. - View Dependent Claims (13)
-
-
14. An osmotic pump for delivery a pharmaceutical agent, comprising:
-
an osmotic engine;
a pharmaceutical agent compartment adapted to contain a volume of the pharmaceutical agent;
a plurality of semipermeable membranes, one end of each of which being in communication with the osmotic engine, each of the plurality of semipermeable membranes being configured to enable an osmotic pressure differential to develop when another end thereof is selectively exposed to fluid from an environment of use, and a rate adjustment assembly configured to selectively expose or cover at least one of the plurality of semipermeable membranes to the environment of use to selectively and reversibly increase or decrease a rate at which the pharmaceutical agent is delivered from the osmotic pump. - View Dependent Claims (15, 16, 17, 18)
-
-
19. A method of non-invasively increasing or decreasing a dose of pharmaceutical agent delivered to a patient by a previously implanted osmotic pump, comprising the steps of:
-
providing a magnet;
positioning the provided magnet on or close to a skin of the patient over the previously implanted osmotic pump, and rotating the positioned magnet by a predetermined degree of rotation, whereby the implanted osmotic pump responds to the rotating magnet by increasing or decreasing the dose of pharmaceutical agent delivered to the patient.
-
Specification