Transgenic animals produced using oral administration of a genetic agent coupled to a transporting agent
First Claim
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1. An in vivo process for producing a transgenic animal comprising:
- providing at least one transporting agent effective for enabling widespread distribution, systemic expression and sustained delivery of at least one genetic material via a natural gastrointestinal pathway, said genetic material designed to express a biological agent;
forming a distributable moiety by coupling said transporting agent and said genetic material;
administering said distributable moiety to an animal;
transporting said distributable moiety in vivo via said natural gastrointestinal pathway whereby said genetic material is included within essentially all cells of said animal; and
genetically altering said animal via intracellular expression of said biological agent;
wherein a transgenic animal is produced.
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Abstract
The present invention is directed toward a method of producing transgenic animals by administration of a composition to an animal via a natural gastrointestinal pathway. The composition achieves widespread distribution, systemic expression and sustained delivery in the animal. More particularly, the invention discloses a method for producing a transgenic animal using oral gene therapy. The present invention also provides transgenic animals produced by this method.
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Citations
20 Claims
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1. An in vivo process for producing a transgenic animal comprising:
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providing at least one transporting agent effective for enabling widespread distribution, systemic expression and sustained delivery of at least one genetic material via a natural gastrointestinal pathway, said genetic material designed to express a biological agent;
forming a distributable moiety by coupling said transporting agent and said genetic material;
administering said distributable moiety to an animal;
transporting said distributable moiety in vivo via said natural gastrointestinal pathway whereby said genetic material is included within essentially all cells of said animal; and
genetically altering said animal via intracellular expression of said biological agent;
wherein a transgenic animal is produced. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20)
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- 6. The process in accordance with clam 1 wherein said step of expressing is tissue specific.
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