Size-exclusion ion-exchange particles
First Claim
1. A size-exclusion ion-exchange particle comprising a core and a shell, wherein the core comprises ion-exchange material, and the shell comprises size-exclusion material.
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Accused Products
Abstract
A size-exclusion ion-exchange particle and a device using the particle are provided wherein the particle includes an ion-exchange core micro-encapsulated by a shell, and the shell includes a polymerization product of a reactive monomer. The shell can be an at least partially cross-linked polymer. The shell can be capable of excluding molecules of a size equal to or larger than a 10 nt ssDNA molecule or molecules of a size equal to or larger than a 100 nt ssDNA molecule, for example, and the core can be capable of ion-exchange. Methods of making size-exclusion ion-exchange particles are also provided, as are methods of purification using the particles.
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Citations
60 Claims
- 1. A size-exclusion ion-exchange particle comprising a core and a shell, wherein the core comprises ion-exchange material, and the shell comprises size-exclusion material.
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12. The particle of 11, wherein the core includes one or more of a poly(N-vinylpyrrolidone) polymer material, a poly(vinyl acetate-co-vinyl alcohol) material, a polyacrylamide material, a poly(N,N-dimethyl acrylamide) material, a poly(N-vinylamide) material, a poly(ethyleneoxide-co-propyleneoxide) material, an amphiphilic diblock copolymer, and an amphiphilic block copolymer.
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31. A method of forming a size-exclusion ion-exchange particle comprising:
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providing an ion-exchange core; and
micro-encapsulating the ion-exchange core with a size-exclusion material. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A method of forming a size-exclusion ion-exchange particle, comprising:
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providing an ion-exchange core;
contacting the core with an emulsion, wherein the emulsion comprises a polymerizable monomer; and
polymerizing the monomer to micro-encapsulate the core, wherein the polymerizing comprises forming a shell comprising a plurality of pores, wherein the plurality of pores exclude material larger than a predetermined size. - View Dependent Claims (49, 50)
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51. A method of purifying a sample, comprising:
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providing a plurality of size-exclusion ion-exchange particles, wherein each particle comprises a core for ion-exchange and a shell for size-exclusion;
contacting the sample with the particles to form a purified sample; and
separating the purified sample from the particles. - View Dependent Claims (52, 53, 54, 55, 56, 57)
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Specification