Method of determining an analyte concentration in a sample from an absorption spectrum
First Claim
1. A method of determining an analyte concentration in a sample, the sample comprising the analyte and a substance, the method comprising:
- providing an absorption spectrum of the sample, the absorption spectrum having an absorption baseline;
shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range; and
subtracting a substance contribution from the absorption spectrum, thereby providing a corrected absorption spectrum substantially free of a contribution from the substance.
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Abstract
A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
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Citations
31 Claims
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1. A method of determining an analyte concentration in a sample, the sample comprising the analyte and a substance, the method comprising:
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providing an absorption spectrum of the sample, the absorption spectrum having an absorption baseline;
shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range; and
subtracting a substance contribution from the absorption spectrum, thereby providing a corrected absorption spectrum substantially free of a contribution from the substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of providing pathlength-insensitive measurements of blood constituents in a sample using infrared (IR) spectroscopy, the method comprising:
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providing an absorption spectrum of the sample, the absorption spectrum having an absorption baseline; and
shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in an absorption wavelength range comprising an isosbestic wavelength at which water and a whole blood protein have approximately equal absorptions.
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30. A method of measuring a pathlength of a sample comprising a first component and a second component, the method comprising:
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providing an absorption spectrum of the sample;
determining an absorption value of the absorption spectrum at an isosbestic wavelength at which the first component and the second component have approximately equal absorption; and
calculating the pathlength from the absorption value.
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31. A method of estimating a glucose concentration of a blood sample, the method comprising:
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measuring sample absorption at a plurality of wavelengths between about 4 microns and 11 microns;
subtracting a contribution to said sample absorption due to the presence of water; and
subtracting a contribution to said sample absorption due to the presence of hemoglobin.
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Specification