Device and method for photoactivation

• US 20040021089A1
• Filed: 06/30/2003
• Published: 02/05/2004
• Est. Priority Date: 03/02/1992
• Status: Active Grant

• Current Assignee: Cerus Corporation
• Original Assignee: Cerus Corporation
• Inventors: Cimino, George D., Simms, Romilly John
• Granted Patent: US 6,949,753 B2
• Time in Patent Office: Days
• US Class Current: 250/428
• CPC Class Codes: A01N 1/0263 Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
• CPC Class Codes: A01N 1/0294 Electromagnetic, i.e. using electromagnetic radiation or electromagnetic fields
• CPC Class Codes: A61K 31/37 Coumarins, e.g. psoralen
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 41/17 by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3683 using photoactive agents
• CPC Class Codes: A61M 1/3686 by removing photoactive agents after irradiation
• CPC Class Codes: A61M 1/369 Temperature treatment

Abstract

Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.

Claims

1. A blood treatment device, comprising:

i) a fluorescent bulb;

ii) a light filtration material configured to remove a blood damaging wavelength of electromagnetic radiation emitted by the fluorescent bulb to produce filtered electromagnetic radiation; and

iii) a blood bag support configured such that at least a portion of the filtered electromagnetic radiation from the bulb contacts a blood bag when positioned on the support.

2. The device of claim 1, wherein the material removes a blood product damaging wavelength that is absorbed by a nucleic acid.

3. The device of claim 1, wherein the material removes a blood product damaging wavelength that is absorbed by a protein.

4. The device of claim 1, wherein the material removes a blood product damaging wavelength that is absorbed by hemes.

5. The device of claim 1, wherein the material removes blood product damaging wavelengths that are absorbed by a nucleic acid, a protein and hemes.

6. The device of claim 5, wherein said filtered electromagnetic radiation has wavelengths between 320 and 400 nm.

7. The device of claim 1, wherein the blood bag support comprises said light filtration material, and said light filtration material comprises a short wavelength cutoff filter.

8. The device of claim 7, wherein the short wavelength cutoff filter is a 320 nm cutoff filter.

9. The device of claim 8, wherein said filtered electromagnetic radiation has wavelengths between 320 and 400 nm.

10. The device of claim 1, wherein said filtered electromagnetic radiation has a wavelength that is absorbed by flavins.

11. A method of treating a blood product in a blood bag, comprising:

a) providing i) a blood bag comprising a photoreactive compound and a blood product suspected of containing a pathogen and ii) a blood treatment device comprising a fluorescent bulb, a light filtration material configured to remove a blood damaging wavelength of electromagnetic radiation emitted by the fluorescent bulb to produce filtered electromagnetic radiation, and a blood bag support configured to receive the filtered electromagnetic radiation;

b) positioning the blood bag on the blood bag support; and

c) irradiating the blood bag with the filtered electromagnetic radiation so as to activate the photoreactive compound and inactivate the pathogen.

12. The method of claim 11, wherein the light filtration material removes a blood product damaging wavelength that is absorbed by a nucleic acid and a protein.

13. The method of claim 12, wherein the material removes blood product damaging wavelengths that are absorbed by a nucleic acid, a protein and hemes.

14. The method of claim 13, wherein said filtered electromagnetic radiation has wavelengths between 320 and 400 nm.

15. The method of claim 11, wherein the photoreactive compound is a psoralen.

16. The method of claim 15, wherein the blood product comprises plasma.

17. The method of claim 16, wherein the blood product comprises platelets.

18. A method of treating a blood product in a blood bag, comprising:

a) providing i) a blood bag comprising a photoreactive compound and a blood product suspected of containing a pathogen and ii) a blood treatment device comprising a fluorescent bulb and a blood bag support, wherein the end of the fluorescent bulb is blocked from irradiating the blood product;

b) positioning the blood bag on the blood bag support; and

c) irradiating the blood bag with the fluorescent bulb so as to activate the photoreactive compound and inactivate the pathogen.

19. The method of claim 18, wherein the photoreactive compound is a psoralen.

20. The method of claim 19, wherein the blood product comprises plasma.

21. The method of claim 20, wherein the blood product comprises platelets.