System and method for optimizing drug theraphy for the treatment of diseases
First Claim
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1. A method of measuring the efficacy of at least one therapeutic agent comprising:
- determining an actual concentration of said at least one therapeutic agent;
determining a pharmacologic exposure using a population pharmacokinetic model for said at least one therapeutic agent;
determining resistance of an etiologic agent towards said at least one therapeutic agent;
determining an inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and using said inhibitory quotient to determine efficacy of said at least one therapeutic agent.
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Abstract
The present invention concerns the optimization of hiv-1 therapy using the combination of a bioanalytical method, population pharmacokinetic models and phenotypic resistance testing.
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Citations
45 Claims
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1. A method of measuring the efficacy of at least one therapeutic agent comprising:
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determining an actual concentration of said at least one therapeutic agent;
determining a pharmacologic exposure using a population pharmacokinetic model for said at least one therapeutic agent;
determining resistance of an etiologic agent towards said at least one therapeutic agent;
determining an inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and using said inhibitory quotient to determine efficacy of said at least one therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of measuring the efficacy of at least one therapeutic agent comprising:
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a) obtaining an actual concentration of at least one therapeutic agent in a patient at a given time using a bioanalytical method;
b) calculating a theoretical concentration of said at least one therapeutic agent in said patient at said time using a first population pharmacokinetic model;
c) obtaining a difference by comparing the theoretical concentration of said at least one therapeutic agent with the actual concentration of said at least one therapeutic agent in a patient;
d) minimizing the difference by changing at least one parameter in the first population pharmacokinetic model in order to generate an optimized population pharmacokinetic model;
e) obtaining resistance data from said patient;
f) determining the inhibitory quotient for said at least one therapeutic agent based on said optimized population pharmacokinetic model and said resistance, and g) using said inhibitory quotient to determine efficacy of said at least one therapeutic agent. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of optimizing at least one therapeutic agent regime comprising:
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determining a pharmacologic exposure using an optimized population pharmacokinetic model for at least one therapeutic agent;
determining resistance of an etiologic agent towards said at least one therapeutic agent;
determining the inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and using said inhibitory quotient to optimize said at least one therapeutic agent regime.
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40. A method for determining a dosage regime for at least one therapeutic agent comprising:
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determining a pharmacologic exposure using an optimized population pharmacokinetic model for at least one therapeutic agent;
determining resistance of an etiologic agent towards said at least one therapeutic agent;
determining the inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and using said inhibitory quotient to determine a dosage regime for at least one therapeutic agent.
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41. A method for providing advice to a physician regarding at least one therapeutic agent for at least one patient comprising:
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determining a pharmacologic exposure using an optimized population pharmacokinetic model for said at least one therapeutic agent;
determining resistance of an etiologic agent towards said at least one therapeutic agent;
determining the inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and using said inhibitory quotient to provide advice to a physician regarding at least one therapeutic agent for at least one patient.
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42. A method for providing a report comprising:
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determining a pharmacologic exposure using an optimized population pharmacokinetic model for said at least one therapeutic agent;
determining resistance of an etiologic agent towards said at least one therapeutic agent;
determining the inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and providing a report regarding comprising at least one entry chosen from the inhibitory quotient and information derived from the inhibitory quotient
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43. A report comprising a normalized inhibitory quotient.
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44. A computer system comprising at least one database comprising at least one inhibitory quotient for at least one patient.
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45. A method of identifying at least one therapeutic agent effective against at least one etiological agent comprising:
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determining a pharmacologic exposure using an optimized population pharmacokinetic model for said at least one therapeutic agent;
determining resistance of said etiologic agent towards said at least one therapeutic agent;
determining the inhibitory quotient for said at least one therapeutic agent based on said pharmacologic exposure and said resistance, and using said inhibitory quotient to identify at least one therapeutic agent effective against at least one etiological agent.
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Specification